Influence of circadian rhythm disorder on nonalcoholic fatty liver disease and related hepatocellular carcinoma

Jinxia ZHU; Guangwei LIU; Peiwei YANG

doi:10.3969/j.issn.1001-5256.2021.10.045

Volume 37 Issue 10

Oct. 2021

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Influence of circadian rhythm disorder on nonalcoholic fatty liver disease and related hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.10.045

1.
The First Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
2.
Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (82003994);

Science and Technology Key Project of Henan Province (182102310272);

Special Research Project of Traditional Chinese Medicine of Henan Province (2018JDZX109);

Special Research Project of Traditional Chinese Medicine of Henan Province (2019JDZX2011)

Received Date: 2021-03-04
Accepted Date: 2021-03-30
Published Date: 2021-10-20

Abstract

Abstract

The influence of circadian rhythm disorder on nonalcoholic fatty liver disease (NAFLD) has attracted more and more attention in recent years, and studies in China and globally have shown that individuals who work in shifts at night or often stay up late have a higher incidence rate of NAFLD-related hepatocellular carcinoma (NAFLD-HCC) than those with regular work and rest. This article summarizes the research advances in the effect of circadian rhythm system on the pathogenesis of NAFLD-HCC by regulating lipid metabolism, glucose metabolism, and intestinal flora, and it is pointed out that restoration of normal circadian rhythm has potential clinical significance in delaying the development and progression of disease.

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References(46)

References

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Influence of circadian rhythm disorder on nonalcoholic fatty liver disease and related hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.10.045

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Influence of circadian rhythm disorder on nonalcoholic fatty liver disease and related hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.10.045

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