Association between immunoglobulin G4-related diseases and autoimmune hepatitis

Lili ZHANG; Aiwen GENG; Chuanwang QI; Jianchun XIAN

doi:10.3969/j.issn.1001-5256.2021.12.050

Volume 37 Issue 12

Dec. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(12): 2972-2975

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Association between immunoglobulin G4-related diseases and autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2021.12.050

Department of Hepatopathy, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China

Research funding:

Jiangsu Taizhou Science and Technology Support Plan (Social Development) Project (TS201813)

Received Date: 2021-08-24
Accepted Date: 2021-09-13
Published Date: 2021-12-20

Abstract

Abstract

With the improvement in people's awareness of diseases and the level of diagnosis and treatment, the incidence rates of immunoglobulin G4-related disease (IgG4-RD) and autoimmune liver disease (AILD) are constantly increasing, and IgG4-related sclerosing cholangitis is the overlapping part of the disease spectrum of IgG4-RD and AILD, while the association between IgG4-related autoimmune hepatitis (IgG4-AIH) and these two diseases remains unclear. This article reviews the hepatic manifestation of IgG4-RD, summarizes the clinical features of IgG4-AIH, and analyzes whether IgG4-AIH is a subtype of AIH or a hepatic involvement of IgG4-RD. It is believed that IgG4-AIH has similar but different clinical manifestations and histopathological features from classical AIH, and IgG4-AIH may be classified as two types, i.e., a subtype of AIH and the liver manifestation of IgG4-RD. The research on the pathogenesis, clinical features, and clinical diagnosis and treatment of IgG4-AIH should be taken seriously in future.
- Immunoglobulin G,
- Hepatitis, Autoimmune,
- Autoimmune Diseases

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References(34)

References

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Association between immunoglobulin G4-related diseases and autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2021.12.050

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Association between immunoglobulin G4-related diseases and autoimmune hepatitis

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