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姓名: 项晓刚
职称: 研究员 副主任医师
单位: 上海交通大学医学院附属瑞金医院 感染科
简历介绍:

2011/07-2015/07,上海交通大学医学院附属瑞金医院,住院医师

2015/08-2016/11,上海交通大学医学院附属瑞金医院,主治医师

2016/12-2020/11,上海交通大学医学院附属瑞金医院,破格副研究员、硕士生导师

2017/06-2019/05,美国国立卫生研究院(NIH)-NIAAA,博士后/访问学者

2020/12-至今,上海交通大学医学院附属瑞金医院,副主任医师、破格研究员、博士生导师

发表论文:

1. Fan Q, Zhu H, Zhao J, Zhuang L, Zhang H, Xie H, Zhang R, Granada JF, Xiang X*, Hu W*, Yan X*. Risk factors for myocardial injury in patients with coronavirus disease 2019 in China. ESC Heart Fail. 2020 Oct 2;7(6):4108-4117. doi: 10.1002/ehf2.13022. PMID: 33006440 (通讯作者)

2. Xiang X#, Feng D#, Hwang S, Ren T, Wang X, Trojnar E, Matyas C, Mo R, Shang D, He Y, Seo W, Shah VH, Pacher P, Xie Q*, Gao B*. Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming of impaired regeneration pathways in mice. J Hepatol. 2020 Apr; 72(4); 736-745. PubMed PMID: 31786256.(第一作者)

3. Lai R#, Xiang X#, Mo R, Bao R, Wang P, Guo S, Zhao G, Gui H, Wang H, Bao S*, Xie Q*. Protective effect of Th22 cells and intrahepatic IL-22 in drug induced hepatocellular injury. J Hepatol. 2015 Feb 12;63(1):148-55. pii: S0168-8278(15)00078-1. doi: 10.1016/j.jhep.2015.02.004. PubMed PMID: 25681556.(第一作者)

4.Mo R#, Lai R#, Lu J#, Zhuang Y, Zhou T, Jiang S, Ren P, Li Z, Cao Z, Liu Y, Chen L, Xiong L, Wang P, Wang H, Cai W, Xiang X*, Bao S*, Xie Q*. Enhanced autophagy contributes to protective effects of IL-22 against acetaminophen-induced liver injury. Theranostics. 2018 Jul 30;8(15):4170-4180. pii: thnov08p4170. doi: 10.7150/thno.25798. PubMed PMID: 30128045.(通讯作者)

5. Xiang X, Hwang S, Feng D, Shah VH, Gao B. Interleukin-22 in alcoholic hepatitis and beyond. Hepatol Int. 2020 Sep;14(5):667-676. pii: 10.1007/s12072-020-10082-6. doi: 10.1007/s12072-020-10082-6. PubMed PMID: 32892258.(第一作者)

6. Mo R#, Wang P#, Lai R#, Li F, Liu Y, Jiang S, Zhao G, Guo S, Zhou H, Lin L, Lu J, Cai W, Wang H, Yu H, Bao S, Xiang X*, Xie Q*. Persistently elevated circulating Th22 reversely correlates with prognosis in HBV-related acute-on-chronic liver failure. J Gastroenterol Hepatol. 2017 Mar;32(3):677-686. doi: 10.1111/jgh.13537. PubMed PMID: 27548078.(通讯作者)

7. Liu K#, Xiang X#, Bao R, Chen R, Liu Y, Xie J, Guo Q, Bao S, Xie Q*, Wang H*. A five years study of antiviral effect of entecavir in Chinese chronic hepatitis B patients. Sci Rep. 2016 Jul 01;6:28779. pii: srep28779. doi: 10.1038ep28779. PubMed PMID: 27364728.(第一作者)

8. Xiang X#, Gui H#, King NJ, Cole L, Wang H, Xie Q*, Bao S*. IL-22 and non-ELR-CXC chemokine expression in chronic hepatitis B virus-infected liver. Immunol. Cell Biol. 2011 Sep 27;90(6):611-9. pii: icb201179. doi: 10.1038/icb.2011.79. PubMed PMID: 21946664.(第一作者)

9. Xiang X, Lu J, Dong Z, Zhou H, Tao W, Guo Q, Zhou X, Bao S, Xie Q*, Zhong J*. Viral sequence evolution in Chinese genotype 1b chronic hepatitis C patients experiencing unsuccessful interferon treatment. Infect Genet Evol. 2010 Dec 13;11(2):382-90. pii: S1567-1348(10)00313-8. doi: 10.1016/j.meegid.2010.11.011. PubMed PMID: 21147266.(第一作者)

10. Lu J#, Xiang X#, Cao Z, Wang W, Zhao G, Tang W, Chen L, Guo S, Zhuang Y, Shi D, Chen L, Bao S, Cai W, Wang H, Zhou H*, Xie Q*. Younger trend of cirrhosis incidence in genotype 3 HCV infected patients in Eastern China. J Med Virol. 2017 Aug 01;89(11):1973-1980. doi: 10.1002/jmv.24894. PubMed PMID: 28671305.(并列第一)

11. Xiaogang Xiang, Qing Xie*. IL-35: A potential therapeutic target for controlling hepatitis B virus infection. J Dig Dis. 2015 Jan;16(1):1-6. doi: 10.1111/1751-2980.12218.(第一作者)

12. Gao B, Xiang X. Interleukin-22 from bench to bedside: a promising drug for epithelial repair. Cell. Mol. Immunol. 2018 Jun 19. pii: 10.1038/s41423-018-0055-6. doi: 10.1038/s41423-018-0055-6. PubMed PMID: 29921965. 

13. Gao B, Ma J, Xiang X. MAIT cells: a novel therapeutic target for alcoholic liver disease? Gut. 2017 Nov 22;67(5):784-786. pii: gutjnl-2017-315284. doi: 10.1136/gutjnl-2017-315284. PubMed PMID: 29167178. 

14. Xia Q, Xiang X, Patel S, Puranik R, Xie Q, Bao S. Characterisation of IL-22 and interferon-gamma-inducible chemokines in human carotid plaque. Int J Cardiol. 2012 Jan 26;154(2):187-9. pii: S0167-5273(11)01967-X. doi: 10.1016/j.ijcard.2011.10.093. PubMed PMID: 22104996. 

15. Xiang X, Hwang S, Gao B. Reply to: "Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?": The search for an optimal mouse model. J Hepatol. 2020 Oct;73(4):982-984. pii: S0168-8278(20)30370-6. doi: 10.1016/j.jhep.2020.06.002. PubMed PMID: 32690377. 

16. Zhai H, Zhang J, Shang D, Zhu C*, Xiang X*. The progress to establish optimal animal models for the study of acute-on-chronic liver failure. Front Med (Lausanne). 2023;10:1087274. doi: 10.3389/fmed.2023.1087274. PubMed PMID: 36844207. (通讯作者)

17. Zhang J, Shang D, Xie Q*, Xiang X*. Systemic inflammation is linked to liver fibrogenesis in patients with advanced chronic liver disease. Liver Int. 2022 Dec 28. doi: 10.1111v.15506. PubMed PMID: 36576152. (通讯作者)

18. Zhang J, Xu J, Tang W, Mo R, Shang D, Lu J, Li Z, Wang X, Shi D*, Xie Q*, Xiang X*. Clinical characteristics and pathogen spectra of parasitic infections in a tertiary hospital of Shanghai: A 13-year retrospective study. Front Public Health. 2022;10:993377. doi: 10.3389/fpubh.2022.993377. PubMed PMID: 36249238. (通讯作者)

19. Zhang J, Zhai H, Yu P, Shang D, Mo R, Li Z, Wang X, Lu J*, Xie Q*, Xiang X*. Human Umbilical Cord Blood Mononuclear Cells Ameliorate CCl4-Induced Acute Liver Injury in Mice via Inhibiting Inflammatory Responses and Upregulating Peripheral Interleukin-22. Front Pharmacol. 2022;13:924464. pii: 924464. doi: 10.3389/fphar.2022.924464. PubMed PMID: 35942221. (通讯作者)

20. Zhao S, Fu H, Zhou T, Cai M, Huang Y, Gan Q, Zhang C, Qian C, Wang J, Zhang Z, Wang X*, Xiang X*, Xie Q*. Alteration of Bile Acids and Omega-6 PUFAs Are Correlated With the Progression and Prognosis of Drug-Induced Liver Injury. Front Immunol. 2022;13:772368. doi: 10.3389/fimmu.2022.772368. PubMed PMID: 35493499. (通讯作者)

21. Shang D, Wang P, Tang W, Mo R, Lai R, Lu J, Li Z, Wang X, Cai W, Wang H, Zhao G*, Xie Q*, Xiang X*. Genetic Variations of ALDH (rs671) Are Associated With the Persistence of HBV Infection Among the Chinese Han Population. Front Med (Lausanne). 2022;9:811639. doi: 10.3389/fmed.2022.811639. PubMed PMID: 35237626. (通讯作者)

主持的科研项目:

1、国家自然科学基金委员会, 面上项目, 82170619, IL-22联合IL-37调控全身炎症反应综合征在阻断慢加急性肝衰竭病程进展中的作用和机制研究, 2022-01-01 至 2025-12-31, 55万元, 在研, 主持

2、上海市医苑新星杰出青年人才,SHWJRS(2021)-99,新型细胞因子IL-22在慢加急性肝衰竭病程中的作用机制及治疗价值,20万元,2021/1-2023/12/31,在研,主持

3、上海市人才发展基金,2020097,调控肝再生平衡在慢加急性肝衰竭病程阻断中的作用和机制研究,30万元,2020/11/1-2023/5/30,30万,在研,主持

4、上海市优秀学术带头人计划(青年),20XD1422600,肝细胞内STAT1/STAT3活性失衡在慢加急性肝衰竭中的作用机制和干预策略研究,2020/10/1-2023/9/30,40万,在研,主持。

5、国家自然科学基金面上项目,81970544,STAT1/STAT3活性失衡在慢加急性肝衰竭中的作用机制及IL-22逆转失衡的潜在治疗价值,2020/1-2023/12,55万,在研,主持。

6、上海交通大学医学院双百人计划-研究型医师,上海市高原高峰学科建设计划,20172008,危重型肝病的早期预警预测及临床干预新策略的研究,2017/7-2020/6,100万,在研,主持。

7、上海市自然基金,17ZR1417700,IL-37在乙型肝炎病毒感染相关肝衰竭病程进展中的作用和机制研究,2017/5-2020/04,20万元,已结题,主持。

8、国家自然科学青年基金项目,81300316,iTr35细胞和IL-35在乙型肝炎病毒感染慢性化中的作用和机制研究,2014/01-2016/12,23万元,已结题,主持。

9、上海高校青年教师培养资助计划,ZZjdyx12020,iTr35细胞和IL-35在乙型肝炎病毒感染慢性化中的作用和机制研究,2013/01-2014/12,5万元,已结题、主持。

10、中国肝炎防治基金会天晴肝病基金,TQGB2011014,Th22细胞相关功能分子在HBV感染慢性化及抗病毒治疗中的作用及临床,2012/07-2014/06,5万元,已结题,主持。

 


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