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姓名: 李婕
职称: 科主任 主任医师
单位: 南京大学医学院附属鼓楼医院 感染性疾病科
简历介绍:

李婕 南京大学医学院附属鼓楼医院 感染性疾病科主任

主任医师,研究员,医学博士,博士后,教授、博士研究生导师。

2011年毕业于浙江大学,获内科学专业博士学位。2015年获香港大学郑裕彤博士奖助金资助前往香港大学肝病学研究国家重点实验室,从事病毒性肝炎的基础研究。2016年在美国斯坦福大学医学中心师从著名肝病学家Mindie H. Nguyen教授,从事脂肪性肝病发病机制研究。

近年来,与美国斯坦福大学、香港大学、浙江大学、北京大学建立了良好的合作交流关系,参与多项国内、外多中心合作研究项目。作为课题负责人主持国家自然科学基金3项及国家科技重大专项(十三五)(子任务)课题、教育部科技发展中心高校产学研创新基金、中国博士后科学基金、山东省自然科学基金项目(面上、重点)、山东省重点研发计划项目、中国肝炎防治基金会项目、济南市科技发展计划项目、南京市医学重点科技发展项目共17项,参与2项国家十一五重大专项,1项973项目,3项国家自然科学基金的研究工作,并作为子课题负责人参与美国斯坦福大学牵头的国际多中心Real-C研究项目。获批国家发明专利2项,获山东省医学科技二等奖(第一位)、山东省科技进步二等奖(第三位)、华夏医学科技奖三等奖(第三位)、山东省高等学校科学技术奖一等奖(第四位)各一项。发表SCI论文60余篇,其中以第一作者/通讯作者在The Lancet Gastroenterology & Hepatology、Hepatology、Clin Gastroenterol Hepato、American Journal of Gastroenterology、Diabetes Care、Liver International、Antiviral Research等国际权威杂志发表SCI论文34篇,累计影响因子300分,累计他引700次,单篇最高引用率>200次,其中3篇入选ESI高被引文章。主(参)编论(译)著5部。相关研究成果多次受邀在欧洲肝病年会、亚太肝病年会、美国消化疾病周、美国肝病年会等国际著名肝病会议进行口头汇报交流,发表会议论文20篇。2018年获山东省首届“齐鲁卫生与健康领军人才培育工程杰青人才”称号。2018年获山东省立医院首届”中青年创新人才”称号。2019年获山东省立医院“科研先进个人”。2020年获山东省立医院“诚仁科研奖励基金”。2022年获“江苏特聘医学专家”称号。

发表论文

1) Jie Li, Biyao Zou, Yee Hui Yeo, Yuemin Feng, Xiaoyu Xie, Dong Hyun Lee, 

Hideki Fujii, Yuankai Wu, Leslie Y. Kam, Fanpu Ji, Xiaohe Li, Nicholas Chien, Mike Wei, Eiichi Ogawa, Changqing Zhao, Xia Wu, Christopher D. Stave, Linda Henry, Scott Barnett, Hirokazu Takahashi, Norihiro Furusyo, Yuichiro Eguchi, Yao-Chun Hsu, Teng-Yu Lee, Wanhua Ren, Chengyong Qin, Dae Won Jun, Hidenori Toyoda, Vincent Wai-Sun Wong,Ramsey Cheung, Qiang Zhu, Mindie H. Nguyen. Prevalence, Incidence, and Outcome of Non-alcoholic Fatty Liver Disease in Asia, 1999-2019: A Systematic Review and Meta-analysis. The Lancet Gastroenterology & Hepatology. 2019 May;4(5):389-398. (IF=45.042)(中科院分区:1区)(ESI高被引论文)

2) Jie Li, Huang DQ, Zou B, Yang H, Hui WZ, Rui F, Yee NTS, Liu C, Nerurkar SN, Kai JCY, Teng MLP, Li X, Zeng H, Borghi JA, Henry L, Cheung R, Nguyen MH. Epidemiology of COVID-19: A Systematic Review and Meta-analysis of Clinical Characteristics, Risk factors and Outcomes. J Med Virol. 2021 Mar;93(3):1449-145 (IF=20.693) (ESI高被引论文)

3) Yingrui Wang#, Qianru Zhu#, Rui Sun#, Xiao Yi#, Lingling Huang, Yifan Hu, Weigang Ge, Huanhuan Gao, Xinfu Ye, Yu Song, Li Shao, Yantao Li, Jie Li*, Tiannan Guo*, Junping Shi* Longitudinal proteomic investigation of COVID-19 vaccination. Protein & Cell. 2022 (IF=15.328)(共同通讯作者)

4) Jie Li, Michael H. Le, Monique T. Barakat, Ramsey C. Cheung, Mindie H. Nguyen. The Changing Epidemiology of Liver Disease Among United States Children and Adolescents from 1999-2016. American Journal of Gastroenterology. 2021 Oct 1;116(10):2068-2078 (IF=12.045) (中科院分区:1区)

5) Jie Li, Ramsey C. Cheung, Nonalcoholic Fatty Liver Disease in Children: where are we? Clinical Gastroenterology and Hepatology (2022), doi: https:// doi.org/ 10.1016/j.cgh.2022.02.008. (IF=13.576) (1区)

6) Zebaohe, Jie Li, Comment on Cai et al. Obesity and COVID-19 severity in a designated hospital in Shenzhen, China. Diabetes Care. 2020; 43:1392-1398 (Letter). Diabetes Care. 2020;43:e160–e161.DOI:10.2337/dc20-1195. (IF=19.112) (中科院分区:1区)(通讯作者)

7) Jie Li, Ramsey C. Cheung, Mindie H. Nguyen, Letter to the Editor: Chronic Hepatitis B and Nonalcoholic Steatohepatitis: Is "Fat" All Bad? Hepatology. 2020;71:768. (IF=17.298) (1区)

8) Jie Li, Mindie H. Nguyen, Screening for fatty liver disease and fibrosis in the elderly population: A call for action. Hepatology. 2022 Aug 11. doi: 10.1002/hep.32727.  (IF=17.298) (1区)

9) Jie Li, Mindie H. Nguyen. Chronic hepatitis B and fatty liver-weal or woe? American Journal of Gastroenterology. 2022 Apr 1;117(4):688. (IF=12.045)(1区)

10) Jie Li, Feng Chen, Min Zheng, Haihong Zhu, Dongjiu Zhao, Weixia Liu, Wei Liu, Chen zhi. Inhibition of STAT1 methylation is involved in the resistance of hepatitis B virus to interferon alpha, Antiviral Research. 2010(85) 463-469. (IF=10.101) (中科院分区:2区)

11) Jie Li, Ha Audrey, Rui Fajuan, Zou Biyao, Yang Hongli, Xue Qi, Hu Xinyu, Xu Yayun, Henry Linda, Barakhat  Monique, Stave Christopher, Shi Jun-Ping, Wu Chao, Cheung Ramsey, Mindie H. Nguyen. Meta-analysis: global prevalence, trend and forecasting of non-alcoholic fatty liver disease in children and adolescents, 2000-2021. Alimentary Pharmacology & Therapeutics. 2022 Jun 23. doi: 10.1111/apt.17096. (IF=9.524)(中科院分区:1区)

12) Jie Li, An K. Le, Kevin T. Chaung, Linda Henry, Joseph K. Hoang, Ramsey Cheung, Mindie H. Nguyen. Fatty liver is not independently associated with rates of complete response to oral antiviral therapy in chronic hepatitis B patients, Liver International. 2020;40:1052-1061. https://doi. org/10.1111/liv.14415. (IF=8.754) (中科院分区:2区)

13) Jie Li, Lung Yi Mak, Danny Wong, James Y. Y. Fung, Wai-Kay Seto, Ching Lung Lai, Man Fung Yuen, The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection, Liver International. 2017 Sep;37(9):1287-1294. (IF=8.754)(中科院分区:2区)

14) Jie Li, Mindie H. Nguyen, Non-alcoholic fatty liver disease (NAFLD) in Asia-More efforts are needed. Liver International. 2020 Dec;40(12):3144 (IF=8.754)(通讯作者)(中科院分区:2区)

15) Jie Li, Mindie H. Nguyen, Non-invasive diagnosis methods are needed in paediatric non-alcoholic fatty liver disease.  Liver International. 2021 May;41(5):1161. (IF=8.754) (中科院分区:2区)

16) Jie Li, Hwai-I Yang, Ming-Lun Yeh, An K. Le, Yee Hui Yeo, Chia-Yen Dai, Scott Barnett, Jian Q. Zhang, Jee-Fu Huang,Huy N. Trinh, Christopher Wong, Clifford Wong, Joseph K.Hoang, Ramsey Cheung, Ming-Lung Yu, Mindie H. Nguyen. Association Between Fatty Liver and Cirrhosis, Hepatocellular Carcinoma, and Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B. Journal of Infectious Diseases. 2021 Jul 15;224(2):294-302 (IF=7.759)(中科院分区:2区)

17) Shao L#, Liu J#, Song Y#, Yang W, Gong L, Lyu Z, Zhu Q, Fu J*, Jie Li*, Shi J*. Serum metabolomics-based heterogeneities and screening strategy for metabolic dysfunction-associated fatty liver disease (MAFLD). Clin Chim Acta. 2022 Dec 19:S0009-8981(22)01416-4. doi: 10.1016/j.cca.2022.12.014. (IF=6.314)(共同通讯作者)

18) Xin Tong, Shengxia Yin, Jian Wang, Rui Huang, Chao Wu, Jun ping Shi, Jie Li. Clinical Impact and possible Mechanisms in Hepatitis B Virus (HBV) infection patients concurrent with Nonalcoholic Fatty Liver Disease (NAFLD). Chinese Medical Journal (Engl). 2022 Jul 20;135(14):1653-16632022 (IF=6.013)(通讯作者)(中科院分区:1区)

19) Jie Li#, Xinyu Hu#, Xuein Yan#,Wu C, Yuemin Nan. Clinical Characteristics, Outcome and possible etiology in Acute severe hepatitis of unknown aetiology in Children. Chinese Medical Journal (Engl). 2022 (IF=6.013) (中科院分区:1区)

20) Jie Li, Wei Wu, Guoping Peng, Feng Chen, Minghui Bai, Min Zheng and Zhi Chen. HBcAg induces Interleukin 10 production, inhibiting HBcAg-specific Th17 responses in chronic hepatitis B patients. Immunology and Cell Biology. 2010 Nov-Dec;88(8):834-41. (IF=5.853) (中科院分区:2区)

21) Jie Li, Jian-Gao Fan. Characteristics and mechanism of liver injury in 2019 coronavirus disease. J Clin Transl Hepatol. 2020;8(1):13-17. (IF=5.065)(ESI高被引论文)(中科院分区:2区)

22) Chuanli Liu, Hongli Yang, Yuemin Feng, Cuihong Liu, Fajuan Rui, Yuankui Cao, Xinyu Hu, Jiawen Xu, Junqing Fan, Qiang Zhu, Jie Li. A KNN model to predict the early recurrence of hepatocellular carcinoma (HCC) after resection. J Clin Transl Hepatol. 2021.DOI: 10.14218/JCTH.2021.00348 (IF=5.065)(中科院分区:2区)(通讯作者)

23) Jian Wang#, Jiacheng Liu#, Yilin Liu#, Ruifei Xue, Jie Zhan, Suling Jiang, Li Wang, Xiaomin Yan, Yali Xiong, Juan Xia, Shengxia Yin, Xin Tong, Yuxin Chen, Jie Li*, Rui Huang*, Chao Wu*. Clinical features of chronic hepatitis B patients with lean non-alcoholic fatty liver disease. Hepatology Research.2022 (IF=4.942)(通讯作者)

24) Jie Li, Wanhua Ren, Wei Ma, Jiao Zhang, Jun Shi, Chengyong Qin, Interleukin-21 responses in patients with Chronic Hepatitis B, J Interferon Cytokine Res. 2015 Feb;35(2):134-42. (IF=3.657) (中科院分区:4区)

25) Fajuan Rui, Hongli Yang, Zhaoyang Guo, Zhengming Ge, Xinyu Hu, Lulu Zhang, Qi Xue, Haiping Chen, Yayun Xu, Meng Tan, Chengyong Qin, Zebao He, Jie Li. Derivation and validation of prognostic models for predicting survival outcomes in Acute-on-chronic liver failure (ACLF) patients. Journal of Viral Hepatitis. 2021 Dec;28(12):1719-1728 (IF=3.517)(通讯作者)(中科院分区:2区)

26) Jie Li, Jun Shi, Wanhua Ren, Wei Wu, Zhi Chen. Regulatory Role of CD4+ CD25+ Foxp3+ Regulatory T Cells on IL-17-Secreting T Cells in Chronic Hepatitis B Patients, Digestive Diseases and Sciences. 2014; 59:1475-83. (IF=3.487) (中科院分区:3区)

27) Jie Li, Matthew S. Chang,Tram T. Tran, Mindie H. Nguyen, Management of Chronic Hepatitis B in Pregnancy, J Clin Gastroenterol. 2017 Oct; 51 (9):789-795. (IF=3.174) (中科院分区:3区)

28) Wei Wu#, Jie Li #, Feng Chen, Haihong Zhu, Guoping Peng, Zhi Chen. Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients. J Gastroenterol Hepatol. 2010 Apr;25(4):750-7. (IF=3.174) (中科院分区:3区)

29) Jie Li, Xizhen Sun, Jianting Fang, Chuanxi Wang, Guoqing Han, Wanhua Ren, Analysis of intrahepatic total HBV DNA, cccDNA and serum HBsAg level in Chronic Hepatitis B Patients with undetectable serum HBV DNA during Oral antiviral therapy, Clin Res Hepatol Gastroenterol. 2017 Dec;41(6):635-643. (IF=3.189) (中科院分区:3区)

30) Jia-Li Xu, Jia-Ping Gu, Li-Yan Wang, Qian-Ru Zhu, Ning-Ning You, Jie Li*, Jie Li*, Jun-Ping Shi*. Aberrant Spontaneous Brain Activity and its Association with Cognitive Function in Non-Obese Nonalcoholic Fatty Liver Disease: A Resting-State fMRI Study.Journal of Integrative Neuroscience.2022 (IF=1.664)(通讯作者)

31) Hu X, Sun L, Guo Z, Wu C, Yu X, Jie Li, Management of COVID-19 patients with chronic liver diseases and liver transplants. Ann Hepatol. 2022 Jan-Feb;27(1):100653. (IF=3.388) (通讯作者)

32) Hongli Yang#, Fajuan Rui#, Rui Li#, Shengxia Yin, Qi Xue, Xinyu Hu, Yayun Xu, Chao Wu, Junping Shi*, Jie Li*, ADAR1 inhibits HBV DNA replication via regulating miR-122-5p in palmitic acid treated HepG2.2.15 cells, Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2022 (IF=3.249) (通讯作者)

33) Zebao He, Fajuan Rui, Zhengming Ge, Rui Huang, Hongli Yang, Lingjun Ying, Haihong Zhao, Chao Wu, Jie Li. Establishment and evaluation of a prediction model of BLR for severity in Coronavirus disease 2019 (COVID-19). Infectious Diseases & Immunity. 2022(通讯作者)

34) Fajuan Rui, Hongli Yang, Xinyu Hu, Qi Xue, Yayun Xu, Junping Shi*, Jie Li*. Renaming NAFLD to MAFLD: Advantages and Potential Changes in Diagnosis, Pathophysiology,Treatment, and Management. Infectious Microbes & Diseases,2022


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