王楠娅，医学博士，吉林大学第一医院I期药物临床试验病房副主任，副教授，博士生导师。曾以访问学者身份留学日本。吉林大学优秀青年教师培育计划；吉大一院优秀人才储备计划。国家自然基金获得者。目前主要从事肝胆肿瘤的综合治疗和创新药物早期临床试验。主要学术兼职：中国抗癌协会青年理事会常务理事；中国抗癌协会肿瘤营养与支持治疗专业委员会青委副主委；中华医学会疼痛学分会癌痛学组委员；中国医师协会肝癌专业委员会委员；中国临床肿瘤学会肝癌专家委员会委员，吉林省健康管理学会临床肿瘤专委会常委、总干事；老年学学会老年肿瘤专业委员会常委，总干事、青委会副主委。以负责人身份获得吉林大学医疗成果奖2项，参与2部教材、4部专著和5部国家级指南和专家共识的编写。第一作者和通讯作者身份发表 SCI 论文 18 篇。主持国家级项目 1 项、省级项目 5 项、院校级项目 6 项，其他社会学术团体科研资助项目2项，共获得科研经费逾200 万。

文章列表：

1．Hou G, Liu B, Fan ZQ, Li C, Zhang JP, Guo YH, Zhang RY, Zheng Y, Zhu H, Wang NY. Association between early response of alpha-fetoprotein and treatment efficacy of systemic therapy for advanced hepatocellular carcinoma: A multicenter cohort study from China. Front Oncol.2023;12:1094104.  

2．Liu B, Shang X, Shi JY, Cui GZ, Li X, Wang NY. Early Alpha-Fetoprotein Response Is Associated With Survival in Patients With HBV-Related Hepatocellular Carcinoma Receiving Lenvatinib. Front Oncol. 2022;12:807189.

3. Wang NY, Qin Y, Du FR, Wang XX, Song C. Prevalence of SWI/SNF genomic alterations in cancer and association with the response to immune checkpoint inhibitors: A systematic review and meta-analysis.Gene.2022;834:146638.

4. Dong D, Shi JY, Shang X, Liu B, Xu WL, Cui GZ, Wang NY. Prognostic significance of sarcopenia in patients with hepatocellular carcinoma treated with lenvatinib: A retrospective analysis. Medicine (Baltimore).2022;101(5):e28680.

6．Wang MD, Wang NY#, Zhang HL, Sun LY, Xu QR, Liang L, et al. Fatty acid transport protein-5 (FATP5) deficiency enhances hepatocellular carcinoma progression and metastasis by reprogramming cellular energy metabolism and regulating the AMPK-mTOR signaling pathway. Oncogenesis,2021,10(11):74.

7. Wang NY, Qin Y, Du FR, Wang XX, Song C. Prevalence of SWI/SNF genomic alterations in cancer and association with the response to immune checkpoint inhibitors: A systematic review and meta-analysis.Gene.2022;834:146638.

8. Shi JY, Wang NY. Is ALPlat criterion justified for predicting posthepatectomy liver failure? Surgery,2020,168(6):1180.

9. Qian L, Dong YB, Zhao LL, Zhao HJ, Cui JW, Wang NY. Survival prediction with score model based on clinical characteristics in advanced HCC patients receiving oxaliplatin-containing regimens. Neoplasma, 2019,66(2):301-7.

10. Wang N, Dong Y, Zhao L, Zhao H, Li W, Cui J. Factors associated with optimal pain management in advanced cancer patients. Curr Probl Cancer. 2019;43(1):77-85.

11.Yang G, Shang X, Cui G, Zhao L, Zhao H, Wang N. Mangiferin Attenuated Diethynitrosamine-Induced Hepatocellular Carcinoma in Sprague-Dawley Rats via Alteration of Oxidative Stress and Apoptotic Pathway. J Environ Pathol Toxicol Oncol. 2019;38(1):1-12.

12. Ma C, Zhao LL, Zhao HJ, Cui JW, Li W, Wang NY. Lentivirus-mediated MDA7/IL24 expression inhibits the proliferation of hepatocellular carcinoma cells. Mol Med Rep,2018,17(4):5764-73.

13. Shi L, Liu Y, He H, Wang C, Li H, Wang N. Characteristics and prognostic factors for pain management in 152 patients with lung cancer. Patient Prefer Adherence. 2016;10:571-577.

14. Qian L, Wang N#, Tian H, Jin H, Zhao H, Niu C, He H, Ge T, Han W, Hu J, Li D, Han F, Xu J, Ding X, Chen J, Li W, Cui J. Dual Effects of Cellular Immunotherapy in Inhibition of Virus Replication and Prolongation of Survival in HCV-Positive Hepatocellular Carcinoma Patients. J Immunol Res. 2016;2016:6837241.

15. Feng D, Wang N# ,Hu J, Li W. Surface markers of hepatocellular cancer stem cells and their clinical potential. Neoplasma.,2014,61(5):505-13.

16. Cui J, Wang N,# Zhao H, Jin H, Wang G, Niu C, Terunuma H, He H, Li W. Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma. Int J Cancer. 2014;134(2):342-351.

17. Wang NY, Wang C, Li W, Wang GJ, Cui GZ, He H, Zhao HJ. Prognostic value of serum AFP, AFP-L3, and GP73 in monitoring short-term treatment response and recurrence of hepatocellular carcinoma after radiofrequency ablation. Asian Pac J Cancer Prev. 2014;15(4):1539-1544.

18. Nanya Wang, Bai Fan, Noriko Miyake, Koichi Miyake, Takashi Shimada; A Single Intramuscular Injection of AAV-8 Vector Expressing MDA7/IL-24 Efficiently Suppresses Tumor Growth Mediated by Multiple Anti-Cancer Mechanisms In Lymphoma Model Mice. Blood 2010; 116 (21): 1474.

课题列表：

1、国家自然基金委，81201673，MDA7/IL-24基因对CD133阳性肝癌肿瘤干细胞的作用与机制

2、北京医卫健康公益基金会，早期血流灌注及标志物特征对肝癌仑伐替尼疗效的预测

3、吉林省科技厅，省自然科学基金，基于iEESI-MS技术的肝细胞癌干细胞代谢组学研究

4、吉林大学第一医院，交叉学科基金，iEESI-MS检测对原发性肝癌免疫治疗疗效的预判

5、吉林大学第一医院，吉林大学第一医院人才储备计划 青年骨干项目