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姓名: 王宝菊
职称: 教授 主任医师
单位: 华中科技大学同济医学院附属协和医院 感染科
简历介绍:

2005年毕业于华中科技大学获内科学博士学位。现任华中科技大学同济医学院附属协和医院感染科副主任、主任医师、教授、硕士生导师。任湖北省医学会感染病学分会委员,武汉医学会肝病学分会副主任委员。曾任中华医学会感染病学分会青年委员、湖北省医学会肝病学分会委员。长期从事感染性疾病的临床、教学和科研工作,在病毒性肝炎肝硬化肝衰竭等肝脏疾病、发热伴血小板减少综合征等传染性疾病、不明原因发热等方面积累了较丰富的经验。

主要研究方向为乙肝及新发突发传染病动物模型的建立及免疫发病机制。主持国家科技支撑计划课题、中德跨学科重大科技合作项目子课题、十三五传染病国家科技重大专项课题任务、国家自然科学基金青年项目各1项,研究经费600余万元。发表SCI论文60余篇,其中在J Hepatol.、mBio等杂志发表第一作者或通讯作者SCI论文10余篇。获湖北省科技进步一等奖(排名第二)。

代表性论文:

1.Xiang T, Liang B, Wang H, Quan X, He S, Zhou H, He Y, Yang D, Wang B*, Zheng X*. Safety and immunogenicity of a SARS-CoV-2 inactivated vaccine in patients with chronic hepatitis B virus infection. Cell Mol Immunol. 2021 Dec;18(12):2679-2681. 

2.Li JQ, Liang X, You SL, Feng TT, Zhou X, Zhu B, Luo JJ, Xin JJ, Jiang J, Shi DY, Lu YY, Ren KK, Wu TZ, Yang LL, Li J, Li T, Cai Q, Sun SW, Guo BB, Xingping Zhou XP, Chen JX, He LL, Li P, Yang H, Hu W, An ZL, Jin XJ, Tian J, Wang BJ*, Chen X*, Xin SJ*, Li J*. Chinese Group on the Study of Severe Hepatitis B (COSSH). Development and validation of a new prognostic score for hepatitis B virus-related acute-on-chronic liver failure. J Hepatol. 2021 Jun 4:S0168-8278(21)00399-8.

3.Guo W#, Zhou X#, Li X#, Zhu Q, Peng J, Zhu B, Zheng X, Lu Y, Yang D, Wang B*, Wang J*. Depletion of Gut Microbiota Impairs Gut Barrier Function and Antiviral Immune Defense in the Liver. Front Immunol. 2021 Mar 25;12:636803.

4.Liu J#*, Yang X#, Wang H, Li Z, Deng H, Liu J, Xiong S, He J, Feng X, Guo C, Wang W, Zelinskyy G, Trilling M, Sutter K, Senff T, Menne C, Timm J, Zhang Y, Deng F, Lu Y, Wu J, Lu M, Yang D, Dittmer U, Wang B*, Zheng X. Analysis of the Long-Term Impact on Cellular Immunity in COVID-19-Recovered Individuals Reveals a Profound NKT Cell Impairment. mBio. 2021 Apr 27;12(2):e00085-21. 

5.Liu Y#, Wang B#, Wang L, Vikash V, Wang Q, Roggendorf M, Lu M, Yang D*, Liu J*. Transcriptome Analysis and Comparison of Marmota monax and Marmota himalayana. PLoS One. 2016 Nov 2;11(11):e0165875. 

6.Yan Q, Li M, Liu Q, Li F, Zhu B, Wang J, Lu Y, Liu J, Wu J, Zheng X, Lu M, Wang B* Yang D*. Molecular characterization of woodchuck IFI16 and AIM2 and their expression in woodchucks infected with woodchuck hepatitis virus (WHV). Sci Rep. 2016 Jun 29;6:28776. 

7.Wang B#, Zhu Z#, Zhu B, Wang J, Song Z, Huang S, Fan W, Tao Y, Wang Z, Wang H, Lu M*, Yang D*. Nucleoside analogues alone or combined with vaccination prevent hepadnavirus viremia and induce protective immunity: Alternative strategy for hepatitis B virus post-exposure prophylaxis. Antiviral Res. 2014 Feb 28;105(5):118-125

8.Wang J#, Wang B#, Huang S, Song Z, Wu J, Zhang E, Zhu Z, Zhu B, Yin Y, Lin Y, Xu Y, Zheng X, Lu M, Yang D. Immunosuppressive drugs modulate the replication of hepatitis B virus (HBV) in a hydrodynamic injection mouse model. PLoS One. 2014 Jan 21;9(1):e85832. 

9.Yang Y, Zhang X, Zhang C, Tao Y, Fan W, Wang Z, Wang H, Lu M, Yang D, Fiedler M*, Wang B*. Molecular characterization of woodchuck CD4 (wCD4) and production of a depletion monoclonal antibody against wCD4. Mol Immunol. 2013 Nov;56(1-2):64-71. 

10.Fan H, Zhu Z, Wang Y, Zhang X, Lu Y, Tao Y, Fan W, Wang Z, Wang H, Roggendorf M, Lu M, Wang B* Yang D*. Molecular characterization of the type I IFN receptor in two woodchuck species and detection of its expression in liver samples from woodchucks infected with woodchuck hepatitis virus (WHV). Cytokine. 2012 Oct;60(1):179-85. 

11.Wang BJ, Bao JJ, Wang JZ, Wang Y, Jiang M, Xing MY, Zhang WG, Qi JY, Roggendorf M, Lu MJ, Yang DL. Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma. World J Gastroenterol. 2011Jul 28;17(28):3322-9. 

12.Wang BJ, Tian YJ, Meng ZJ, Jiang M, Wei BQ, Tao YQ, Fan W, Li AY, Bao JJ, Li XY, Zhang ZM, Wang ZD, Wang H, Roggendorf M, Lu MJ, Yang DL. Establishing a new animal model for hepadnaviral infection: susceptibility of Chinese Marmota-species to woodchuck hepatitis virus infection. J Gen Virol. 2011 Mar;92(Pt 3):681-91

13.Wang B, Lohrengel B, Lu Y, Meng Z, Xu Y, Yang D, Roggendorf M, Lu M. Molecular characterization of woodchuck interleukin 15 (wIL-15) and detection of its expression in liver samples of woodchucks infected with woodchuck hepatitis virus (WHV). Cytokine. 2005 Dec 21;32(6):296-303. 

 


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