长期从事肝病的临床和科研工作,擅长各类肝病、肝硬化、肝衰竭和疑难复杂肝病的诊治,担任中华医学会肝病学会青年学组委员、中华医学会肝病学分会自免肝学组委员、中华医学会肝病学分会药物肝学组委员、中华医学会感染病学会青年学组委员、福建省医学会感染病学会常委、福建省医学会肝病学会委员、福州市医学会罕见病学分会副主任委员、《Infectious Diseases & Immunity》杂志审稿人等学术职务主持承担国家自然科学基金(面上)、福建省自然科学基金(面上)、福建省卫生健康中青年骨干培养项目等国家级和省部级课题5项,参与国家“十二五”、“十三五”艾滋病和病毒性肝炎等传染病重大专项研究,作为副主编或编委出版专著3部,发表SCI论文20余篇。
主持科研课题:
1.国家自然科学基金面上项目: Toll样受体信号通路及miR-155在慢性乙型肝炎患者自然
杀伤细胞功能失衡中的作用及机制研究(2017.1-2021.12,58万元,主持)
2.“十三五”重大传染病防治科技专项:血小板ADP抑制率作为乙肝相关终末期肝病分层诊断
新型标记物的验证性研究(2018.1-2021.12,57万元,子任务负责人)
3.福建省卫生健康中青年骨干人才培育项目:肠道菌群介导LPS/AMPK通路在浒苔多糖改善
NAFLD肝纤维化的作用及调控机制(2023.1-2025.12,10万元,主持)
4.福建省自然科学基金面上项目:中性粒细胞胞外诱捕网在慢加急性肝衰竭中的作用
(2020.11-2023.11,7万元,主持)
5.福建省自然科学基金面上项目:Toll样受体信号通路及其下游miR-155参与慢性乙型肝炎
患者自然杀伤细胞功能调控的作用及机制(2015.1-2017.12,8万元,主持)
6.福州市卫生健康科技计划项目:靶向Toll样受体8信号通路调控慢性乙型肝炎患者自然杀
伤细胞功能的研究(2020.10-2023.10,16万元,主持)
发表论文:
1.Ao Xiulan,...,Huang Zuxiong*. TLR8 agonist partially improves IFN-γ deficiency of NK cells in
chronic hepatitis B through the synergy of monocytes.[J] .Aliment Pharmacol Ther, 2023.PMID:36585909
2.Qiuxiang Lin,...,Huang Zuxiong*.Alteration of Gut Microbiota in Primary Biliary Cholangitis
Patients with Non-Response to Ursodeoxycholic Acid.[J].J. Biol. Regul. Homeost. Agents. 2022; 36(4): 1137–1145
3.Huang Zuxiong,Ge Jun, et al. Aberrant expression and dysfunction of TLR2 and its soluble form
in chronic HBV infection and its regulation by antiviral therapy.[J] .Antiviral Res, 2015, 118: 10-9.
4.Huang Zuxiong,Lin Chun,et al. Acute kidney injury in hepatitis B-related acute-on-chronic liver
failure without preexisting liver cirrhosis.[J] .Hepatol Int, 2015, 9: 416-23.
5.Zeng Da-Wu#,Huang Zu-Xiong#, et al. A novel HBsAg-based model for predicting significant
liver fibrosis among Chinese patients with immune-tolerant phase chronic hepatitis B: a multicenter retrospective study.[J] .Therap Adv Gastroenterol, 2021, 14: 17562848211010675.(共同一作)
6.Ge Jun#,Huang Zuxiong#, et al. Lower Expression of MicroRNA-155 Contributes to Dysfunction
of Natural Killer Cells in Patients with Chronic Hepatitis B.[J] .Front Immunol, 2017, 8: 1173.(共同一作)
7.Jiang Xiuhua,Huang Zuxiong#,et al. Design for a Multicentre Prospective Cohort for the
Assessment of Platelet Function in Patients with Hepatitis-B-Virus-Related Acute-on-Chronic Liver Failure.[J] .Clin Epidemiol, 2022, 14: 997-1011.(共同一作)