中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 1
Jan.  2020
Turn off MathJax
Article Contents

Formation mechanism of neutrophil extracellular traps and their role in liver diseases

DOI: 10.3969/j.issn.1001-5256.2020.01.049
Research funding:

 

  • Published Date: 2020-01-20
  • Neutrophil extracellular traps(NETs) have recently been found to be a new immune mechanism for neutrophils to kill pathogens.The main component of NETs is DNA,with granular proteins of different sizes attached to the surface. NETs play different roles in various liver diseases such as hepatic ischemia-reperfusion injury,chronic hepatitis B,liver cirrhosis,and liver cancer. This article reviews the formation mechanism,structure,and role of NETs in liver diseases.

     

  • loading
  • [1] SILVESTRE C,FRIDLENDER G,GLOGAUER M,et al. Neutrophil diversity in health and disease[J]. Trends Immunol,2019,40(7):565-583.
    [2] RADA B. NADPH oxidases:Methods in molecular[M]. New York:Humana,1982:517-528.
    [3] CASTANHEIRA F,KUBES P. Neutrophils and NETS in modulating acute and chronic inflammation[J]. Blood,2019,133(20):1-20.
    [4] JORCH SK,KUBES P. An emerging role for neutrophil extracellular traps in noninfectious disease[J]. Nat Med,2017,23(3):279.
    [5] TAKEI H,ARAKI A,WATANABE H,et al. Rapid killing of human neutrophils by the potent activator phorbol 12-myristate13-acetate(PMA)accompanied by changes different from typical apoptosis or necrosis[J]. J Leukoc Biol,1996,59(2):229-240.
    [6] BRINKMANN V,REICHARD U,GOOSMANN C,et al. Neutrophil extracellular traps kill bacteria[J]. Science,2004,303(5663):1532-1535.
    [7] PRUCHNIAK MP,KOTULA I,MANDA HA. Neutrophil extracellular traps(Nets)impact upon autoimmune disorders[J].Cent Eur J Immunol,2015,40(2):217-224.
    [8] HONDA M,KUBES P. Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system[J]. Nat Rev Gastroenterol Hepatol,2018,15(4):206-221.
    [9] ROCHAEL NC,GUIMARAES AB,NASCIMENTO MT,et al.Classical ROS-dependent and early/rapid ROS-independent release of Neutrophil Extracellular Traps triggered by Leishmania parasites[J]. Sci Rep,2015,5:18302.
    [10] FUCHS TA,ABED U,GOOSMANN C,et al. Novel cell death program leads to neutrophil extracellular traps[J]. J Cell Biol,2007,176(2):231-241.
    [11] ZHU Y,YANG Y,LI F,et al. Stimulation of the class-A scavenger receptor induces neut-rophil extracellular traps(NETs)by ERK dependent NOX2 and ROMO1 activation[J]. Biochem Biophys Res Commun,2019,511(4):1-8.
    [12] KAWAKAMI T,HE J,MORITA H,et al. Rab27a is essential for the formation of neutrophil extracellular traps(NETs)in neutrophil-like differentiated HL60 cells[J]. PLo S ONE,2014,9(1):1-11.
    [13] MAREN KB,VICTOR N. Innate immunity turned inside-out:Antimicrobial defense by phagocyte extracellular traps[J]. J Mol Med,2009,87(8):775-783.
    [14] BRINKMANN V,ZYCHLINSKY A. Neutrophil extracellular traps:Is immunity the second function of chromatin?[J]. J Cell Biol,2012,198(5):773-783.
    [15] ORTMANN W,KOLACZKOWSKA E. Age is the work of art? Impact of neutrophil and organism age on neutrophil extracellular trap formation[J]. Cel Tissue Res,2018,371(3):473-488.
    [16] LI H,FENG D,CAI Y,et al. Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin-2 and NET[J]. Hepatology,2018,68(4):1604-1620.
    [17] NEUMANN A,VOLLGER L,BERENDS ET,et al. Novel role of the antimicrobial peptide LL-37 inthe protection of neutrophil extracellular traps against degradation by bacterialnuclease[J]. J Innate Immun,2014,6(6):860-868.
    [18] DABROWSKA D,JABLONSKA E,GARLEY M,et al. New aspects of the biology of neutrophil extracellular traps[J]. Scand J Immunol,2016,84(6):317-322.
    [19] VANDERWINDT DJ,SUD V,ZHANG H,et al. neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in non-alcoholic steatohepatitis[J].Hepatology,2018,68(4):1-48.
    [20] HUANG H,TOHME S,AL-KHAFAJI AB,et al. DAMPs-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury[J]. Hepatology,2015,62(2):600-614.
    [21] DUARTE S,MATIAN P,MA S,et al. Adeno-associated virus–mediated gene transfer of tissue inhibitor of metal oproteinases-1impairs neutrophil extracellular trap formation and ameliorates hepatic ischemia and reperfusion injury[J]. Am J Pathol,2018,188(8):1820-1832.
    [22] ARUMUGAM S,GIRISH SK,KEMPARAJU K,et al. Neutrophil extracellular traps in acrolein promoted hepatic ischemia reperfusion injury:Therapeutic potential of NOX2 and p38MAPK inhibitors[J]. J Cell Physiol,2018,233(4):3244-3261.
    [23] SETO WK,LO YR,PAWLOTSKY JM,et al. Chronic hepatitis B virus infection[J]. Lancet,2018,392(10161):2313-2324.
    [24] HU S,LIU X,GAO Y,et al. Hepatitis B virus inhibits neutrophil extracellular trap release by modulating reactive oxygen species production and autophagy[J]. J Immunol,2019,202(3):805-815.
    [25] MAN SS. Influence of hepatitis B virus on the formation of neutrophil extracellular traps[D]. Jinan:University of Jinan,2015.(in Chinese)满姗姗.HBV对中性粒细胞胞外诱捕网形成的影响[D].济南:济南大学,2015.
    [26] YU X,LAN P,HOU X,et al. HBV inhibits LPS-induced NLRP3inflammasome activation and IL-1βproduction via suppressing NF-κB pathway and ROS production[J]. J Hepatol,2017,66(4):693-702.
    [27] LEU CM,LU YC,PENG WL,et al. The hepatitis B virus e antigen suppresses the respiratory burst and mobility of human monocytes and neutrophils[J]. Immunobiology,2014,219(11):880-887.
    [28] BARNETT R. Liver cirrhosis[J]. Lancet,2018,392(10144):275.
    [29] ROLAS L,MAKHEZER N,HADJOUDJ S,et al. Inhibition of mammalian target of rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis[J]. Hepatology,2013,57(3):1163-1171.
    [30] AGRAZCIBRIAN JM,SEGURAORTEGA JE,DELGADORIZO V,et al. Alterations in neutrophil extracellular traps is associated with the degree of decompensation of liver cirrhosis[J]. J Infect Dev Ctries,2016,10(5):512-517.
    [31] AGRAZCIBRIAN JM,DELGADORIZO V,SEGURAORTEGA JE,et al. Impaired neutrophil extracellular traps and inflammatory responses in the peritoneal fluid of patients with liver cirrhosis[J]. Scand J Immunol,2018,88(5):12714.
    [32] SEO JD,GU JY,JUNG HS,et al. Contact system activation and neutrophil extracellular trap markers:Risk factors for portal vein thrombosis in patients with hepatocellular carcinoma[J].Clin Appl Thromb Hemost,2019,25:1-6.
    [33] TOHME S,YAZDANI HO,ALKHAFAJI AB,et al. Neutrophil extracellular traps promote the development and progression of liver metastases after surgical stress[J]. Cancer Res,2016,76(6):1367-1380.
    [34] JELLE A,ROBERT JP,TON L,et al. Elevated plasma levels of cell-free DNA during orthotopic liver transplantation are associated with activation of coagulation[J]. Liver Transplantation,2019,25(1):180-181.
    [35] STOIBER W,OBERMAYER A,STEINBACHER P,et al. The role of reactive oxygen species(ROS)in the formation of extracellular traps(ETs)in humans[J]. Biomolecules,2015,5(2):702-723.
    [36] SHAN S,JIA JD. Advances and challenge in prevention and treatment of hepatitis B in China[J]. Chin J Viral Dis,2017,7(1):5-8.(in Chinese)单姗,贾继东.我国乙型肝炎防治成就及机遇和挑战[J].中国病毒病杂志,2017,7(1):5-8.
    [37] DAI SL,YAO J,XU YP. Research progress of targeting hepatitis B virus core protein in treatment of chronic hepatitis B[J].China Med Herald,2018,15(22):35-38.(in Chinese)戴胜兰,姚俊,许亚平.靶向乙肝病毒核心蛋白治疗慢性乙型肝炎的研究进展[J].中国医药导报,2018,15(22):35-38.
    [38] OTT JJ,STEVENS GA,GROEGER J,et al. Global epidemiology of hepatitis B virus infection:New estimates of age-specific HBsAg seroprevalence and endemicity[J]. Vaccine,2012,30(12):2212-2219.
    [39] MARZENA G,EWA J,DOROTA D. NETs in cancer[J]. Tumor Biol,2016,37(11):14355-14361.
    [40] LI J. Epidemiology characteristics of nonalcoholic fatty liver disease in Asia[J]. J Clin Hepatol,2018,34(12):2515-2519.(in Chinese)李婕.亚洲地区非酒精性脂肪性肝病的流行病学特点[J].临床肝胆病杂志,2018,34(12):2515-2519.
    [41] LI M,HE Y,ZHOU ZH,et al. MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6–p47phox–oxidative stress pathway in neutrophils[J]. Gut,2017,66(4):705-715.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1231) PDF downloads(233) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return