中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 6
Jun.  2020
Turn off MathJax
Article Contents

Clinical application of transient elastography in liver cirrhosis and its complications

DOI: 10.3969/j.issn.1001-5256.2020.06.037
Research funding:

 

  • Received Date: 2020-02-08
  • Published Date: 2020-06-20
  • Liver cirrhosis is a pathological stage in which most chronic liver diseases progress to the advanced stages,and the main complications of liver cirrhosis include portal hypertension,gastroesophageal variceal bleeding,and liver cancer. Transient elastography( TE) uses acoustic waves to obtain liver stiffness measurement( LSM) noninvasively and is currently widely used in clinical practice. At present,various studies on LSM and liver cirrhosis and its complications suggest that TE has the ability to identify liver cirrhosis and its complications and can thus reduce unnecessary invasive procedures to a certain degree. This article summarizes and elaborates on the advances in the clinical application of TE in liver cirrhosis and its complications.

     

  • loading
  • [1] Chinese Society of Hepatology,Chinese Medical Association.Chinese guidelines on the management of liver cirrhosis[J]. J Clin Hepatol,2019,35(11):2408-2425.(in Chinese)中华医学会肝病学分会.肝硬化诊治指南[J].临床肝胆病杂志,2019,35(11):2408-2425.
    [2] YANG S,WU J,DING C,et al. Epidemiological features of and changes in incidence of infectious diseases in China in the first decade after the SARS outbreak:An observational trend study[J]. Lancet Infect Dis,2017,17(7):716-725.
    [3] Chinese Society of Hepatology,Chinese Medical Association;Chinese Society of Gastroenterology,Chinese Medical Association; Chinese Society of Endoscopy,Chinese Medical Association. Guidelines for the diagnosis and treatment of esophageal and gastric variceal bleeding in cirrhotic portal hypertension[J]. J Clin Hepatol,2016,32(2):203-217.(in Chinese)中华医学会肝病学分会,中华医学会消化病学分会,中华医学会内镜学分会.肝硬化门静脉高压食管胃静脉曲张出血的防治指南[J].临床肝胆病杂志,2016,32(2):203-217.
    [4] COLECCHIA A,COLLI A,CASAZZA G,et al. Spleen stiffness measurement can predict clinical complications in compensated HCV-related cirrhosis:A prospective study[J]. J Hepatol,2014,60(6):1158-1164.
    [5] RIPOLL C,GROSZMANN R,GARCIA-TSAO G,et al. Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis[J]. Gastroenterology,2007,133(2):481-488.
    [6] LDINGHEN VD,VERGNIOL J. Transient elastography for the diagnosis of liver fibrosis[J]. Expert Rev Med Devices,2010,7(6):811-823.
    [7] DUAN WJ,WANG XM,WANG Y,et al. Comparison of FibroTouch and FibroScan for the assessment of fibrosis in chronic hepatitis B patients[J]. Chin J Exp Clin virol,2018,32(4):399-402.(in Chinese)段维佳,王晓明,王宇,等.FibroTouch和FibroScan检测评估慢性乙型肝炎患者肝纤维化程度的诊断价值[J].中华实验和临床病毒学杂志,2018,32(4):399-402.
    [8] Expert Committee on Consensus of Clinical Application of Transient Elastography(TE). Consensus on clinical application of transient elastography(2015)[J/CD]. Chin J Liver Dis(Electronic Version),2015,7(2):12-18.(in Chinese)瞬时弹性成像技术(TE)临床应用共识专家委员会.瞬时弹性成像技术(TE)临床应用专家共识(2015年)[J/CD].中国肝脏病杂志(电子版),2015,7(2):12-18.
    [9] TSOCHATZIS E A,GURUSAMY K S,NTAOULA S,et al. Elastography for the diagnosis of severity of fibrosis in chronic liver disease:A meta-analysis of diagnostic accuracy[J]. J Hepatol,2011,54(4):650-659.
    [10] CASTERA L,FORNS X,ALBERTI A. Non-invasive evaluation of liver fibrosis using transient elastography[J]. J Hepatol,2008,48(5):835-847.
    [11] VIZZUTTI F,ARENA U,ROMANELLI RG,et al. Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis[J]. Hepatology,2007,45(5):1290-1297.
    [12] MANATSATHIT W,SAMANT H,KAPUR S,et al. Accuracy of liver stiffness,spleen stiffness,and LS-spleen diameter to platelet ratio score in detection of esophageal varices:Systemic review and meta-analysis[J]. J Gastroenterol Hepatol,2018,33(10):1696-1706.
    [13] CALVARUSO V,CACCIOLA I,LICATA A,et al. Is transient elastography needed for noninvasive assessment of high-risk varices? The real experience[J]. Am J Gastroenterol,2019,114(8):1275-1282.
    [14] JANGOUK P,TURCO L,de OLIVEIRA A,et al. Validating,deconstructing and refining Baveno criteria for ruling out high-risk varices in patients with compensated cirrhosis[J]. Liver Int,2017,37(8):1177-1183.
    [15] TOSETTI G,PRIMIGNANI M,LA MURA V,et al. Evaluation of three“beyond Baveno VI”criteria to safely spare endoscopies in compensated advanced chronic liver disease[J]. Dig Liver Dis,2019,51(8):1135-1140.
    [16] ALVAREZ MA,CIRERA I,SOLR,et al. Long-term clinical course of decompensated alcoholic cirrhosis:A prospective study of 165 patients[J]. J Clin Gastroenterol,2011,45(10):906-911.
    [17] PU K,SHI JH,WANG X,et al. Diagnostic accuracy of transient elastography(FibroScan)in detection of esophageal varices in patients with cirrhosis:A meta-analysis[J]. World J Gastroenterol,2017,23(2):345-356.
    [18] BUREAU C,METIVIER S,PERON JM,et al. Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease[J]. Aliment Pharmacol Ther,2008,27(12):1261-1268.
    [19] HERNNDEZ-GEA V,ARACIL C,COLOMO A,et al. Development of ascites in compensated cirrhosis with severe portal hypertension treated withβ-blockers[J]. Am J Gastroenterol,2012,107(3):418-427.
    [20] FERRAIOLI G,WONG VW,CASTERA L,et al. Liver ultrasound elastography:An update to the World Federation for Ultrasound in Medicine and Biology Guidelines and Recommendations[J]. Ultrasound Med Biol,2018,44(12):2419-2440.
    [21] ROBIC MA,PROCOPET B,METIVIER S,et al. Liver stiffness accurately predicts portal hypertension related complications in patients with chronic liver disease:A prospective study[J]. J Hepatol,2011,55(5):1017-1024.
    [22] SALAVRAKOS M,PIESSEVAUX H,KOMUTA M,et al. Fibroscan reliably rules out advanced liver fibrosis and significant portal hypertension in alcoholic patients[J]. J Clin Gastroenterol,2019,53(10):772-778.
    [23] KIM SU,LEE JH,KIM DY,et al. Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis[J]. PLo S One,2012,7(5):e36676.
    [24] PANG JX,ZIMMER S,NIU S,et al. Liver stiffness by transient elastography predicts liver-related complications and mortality in patients with chronic liver disease[J]. PLo S One,2014,9(4):e95776.
    [25] WALLACE MC,PREEN D,JEFFREY GP,et al. The evolving epidemiology of hepatocellular carcinoma:A global perspective[J].Expert Rev Gastroenterol Hepatol,2015,9(6):765-779.
    [26] SINGH S,FUJII LL,MURAD MH,et al. Liver stiffness is associated with risk of decompensation,liver cancer,and death in patients with chronic liver diseases:A systematic review and meta-analysis[J]. Clin Gastroenterol Hepatol,2013,11(12):1573-1584.
    [27] KUO YH,LU SN,HUNG CH,et al. Liver stiffness measurement in the risk assessment of hepatocellular carcinoma for patients with chronic hepatitis[J]. Hepatol Int,2010,4(4):700-706.
    [28] LI M,NIE QH,LONG ZZ,et al. Diagnosis of hepatocellular carcinoma by transient elastography(FibroScan)[J]. Chin J Ultrasonogr,2016,25(10):865-869.(in Chinese)李汨,聂青和,龙振昼,等.FibroScan对原发性肝癌的诊断价值[J].中华超声影像杂志,2016,25(10):865-869.
    [29] OGASAWARA N,SAITOH S,AKUTA N,et al. Advantage of liver stiffness measurement before and after direct-acting antiviral therapy to predict hepatocellular carcinoma and exacerbation of esophageal varices in chronic hepatitis C[J]. Hepatol Res,2020,50(4):426-438.
    [30] PAPATHEODORIDIS GV,SYPSA V,DALEKOS GN,et al.Hepatocellular carcinoma prediction beyond year 5 of oral therapy in a large cohort of Caucasian patients with chronic hepatitis B[J]. J Hepatol,2020.[Online ahead of print]
    [31] CHEN X,PENG YH,HU ZH,et al. Application value of the liver stiffness measurement on complications after hepatectomy[J]. Chin J Dig Surg,2018,17(5):466-473.(in Chinese)陈熙,彭永海,胡朝辉,等.肝硬度值预测肝癌肝切除术后并发症的应用价值[J].中华消化外科杂志,2018,17(5):466-473.
    [32] TAO MM,ZHANG Y,HOU QB. Study on the diagnostic value of transient elastography in the development of cholestasis hepatic fibrosis[J]. Clin J Med Offic,2019,47(6):565-566.(in Chinese)陶苗苗,张炎,侯庆兵.瞬时弹性成像技术肝硬度值测定在胆汁淤积性肝纤维化病变进展中诊断价值研究[J].临床军医杂志,2019,47(6):565-566.
    [33] SHEN Y,WU SD,WU L,et al. The prognostic role of liver stiffness in patients with chronic liver disease:A systematic review and dose-response meta-analysis[J]. Hepatol Int,2019,13(5):560-572.
    [34] BLOOM S,KEMP W,NICOLL A,et al. Liver stiffness measurement in the primary care setting detects high rates of advanced fibrosis and predicts liver-related events in hepatitis C[J]. J Hepatol,2018,69(3):575-583.
    [35] SERRA-BURRIEL M,GRAUPERA I,TORN P,et al. Transient elastography for screening of liver fibrosis:Cost-effectiveness analysis from six prospective cohorts in Europe and Asia[J]. J Hepatol,2019,71(6):1141-1151.
    [36] WONG GL,LIANG LY,KWOK R,et al. Low risk of variceal bleeding in patients with cirrhosis after variceal screening stratified by liver/spleen stiffness[J]. Hepatology,2019,70(3):971-981.
    [37] van KATWYK S,COYLE D,COOPER C,et al. Transient elastography for the diagnosis of liver fibrosis:A systematic review of economic evaluations[J]. Liver Int,2017,37(6):851-861.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (700) PDF downloads(163) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return