2型糖尿病合并脂肪肝的危险因素分析

陈明卫; 杨明功; 王佑民; 王长江; 潘天荣; 胡红琳; 孙海燕

2型糖尿病合并脂肪肝的危险因素分析

详细信息

中图分类号: R575.5
计量
- 文章访问数: 2421
- HTML全文浏览量: 22
- PDF下载量: 717
- 被引次数: 0
出版历程
- 出版日期: 2004-01-20

Risk factors analysis on nonalcoholic steatohepatitis in patients with type 2 diabetes

摘要

摘要: 探讨影响糖尿病合并脂肪肝的主要危险因素。采用病例对照研究 ,2型糖尿病伴有脂肪肝（DFL）组 10 8例 ,2型糖尿病不伴脂肪肝（NDFL）组 139例 ,非糖尿病非酒精性脂肪肝（NDNASH）组 5 2例。与DFL有关的危险因素包括体重指数、腰臀比值、血压、空腹胰岛素、餐后 2小时胰岛素、胆固醇、甘油三酯、HOMA -IR（胰岛素抵抗指数） ;NDFL与NDNAS组比较 ,HOMA -IR差异无显著性。影响DFL的因素众多 ,主要因素是腰臀比值、甘油三酯 ;脂肪肝可能是糖尿病前的一个阶段 ,DFL可能是代谢综合征的一个组成部分。
- 脂肪肝 /
- 2型糖尿病 /
- 胰岛素抵抗 /
- 危险因素
Abstract: To explore the risk factors associated with diabetic fatty liver (DFL) . The investigation was conducted by means of case control study, including 108 patients of type 2 diabetes with fatty liver (DFL) , 139 type 2 diabetes without fatty liver (NDFL) , 52 nondiabetic nonalcoholic steatohepatitis (NDNASH) . Risk factors related to DFL including BMI, WHR, SBP, DBP, FINS, PINS, TC, TG and HOMA-IR. There was no significant difference between NDFL and NDNASH groups on HOMA-IR. The risk factor of DFL includes BMI, WHR, SBP, DBP, FINS, PINS, TC, TG and HOMA-IR. WHR and TG are the most important factors of all. Fatty liver was probably one prediabetic stage, DFL was probably one of components of matebolic syndrome.
- Fatty liver /
- type 2 diabetes mellitus /
- Insulin resistance /
- Risk factors

HTML全文

参考文献(9)

[1] BaconBR , FarahvashMJ, JanneyCG , etal.Nonalcoholicsteatohepati tis:anexpandedclinicalentity[J].Gastroenterology, 1994, 107∶1103-1109.

[2]ShethSG , GordonFD , ChopraS .Nonalcoholicsteatoheptitis[J].AnnInternMed, 1997, 126 (2) ∶137-145.

[3]MatthewsDR , HoskerJP , RudenskiAS , etal.Homeostasismodelas sessment:insulinresistanceandbeta-cellfunctionfromfastingplasmaglucoseandinsulinconcentrationsinman[J].Diabetologia, 1985, 28 (7) -419.

[4] PaulA .Nonalcoholicfattyliverdisease[J].NEnglJMed, 2002, 346 (16) ∶1221-1231.

[5] CortesPH , CamiloME , BaptistaA , etal.Nonalcoholicfattyliver:an otherfeatureofthemetabolicsyndrome?[J].ClinNutr, 1999, 18∶353-358.

[6] KumarKS , MaletPF .Nonalcoholicsteatohepatitis[J].MayoClinProc, 2000, 75 (7) ∶733-739.

[7] MarchesiniG , BriziM , Morselli-LabateAM , etal.Associationofnon alcoholicfattyliverdiseasewithinsulinresistance[J].AmJMed, 1999, 107 (5) ∶450-455.

[8] LuyckxFH , LefebvrePJ, ScheenAJ.Nonalcoholicsteatohepatitis:asso ciationwithobesityandinsulinresistance, andinfluenceofweightloss[J].DiabetesMetab, 2000, 26∶98-106.

[9] ParesA , TresserrasR , NunezI, etal.Prevalenceandfactorsassociatedtothepresenceoffattyliverinapparentlyhealthadultmen[J].MedClinBarc, 2000, 114∶561-565.

施引文献

资源附件(0)

访问统计