肝炎肝硬化合并免疫性血小板减少症临床特点分析(附8例报道)

张世斌; 王征; 米军; 吴燕京; 金瑞

肝炎肝硬化合并免疫性血小板减少症临床特点分析(附8例报道)

首都医科大学附属北京佑安医院

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中图分类号: R575.2
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出版历程
- 出版日期: 2011-08-20

The analysis of the clinical characteristics of patients with liver cirrhosis and immune thrombocytopenia

摘要

摘要: 目的总结分析肝炎肝硬化血小板明显下降患者的临床表现及其原因,藉此探讨和交流诊治经验。方法对8例肝炎肝硬化合并进行性血小板下降的患者,回顾分析其肝功能指标、凝血指标及免疫学指标以及各指标之间的相关性。结果 8例患者血小板进行性下降与其肝硬化严重程度不成比例,并能够除外严重感染、弥漫性血管内凝血、再生障碍性贫血、淋巴瘤、血栓性血小板减少性紫癜等血液系统疾病,抗血小板抗体阳性,诊断为免疫性血小板减少症,应用丙种球蛋白、激素治疗后血小板明显升高。结论肝炎肝硬化患者血小板短期内明显下降时,应考虑合并免疫性血小板减少症,并予以相应的治疗。
- 血小板减少 /
- 自身免疫疾病 /
- 肝炎,病毒性,人 /
- 肝硬化
Abstract: Objective To summarize and analyze the clinical manifestations of cirrhotic patients with severe thrombocytopenia and its underlying etiology.Methods Eight patients of post-hepatitic cirrhosis with progressive thrombocytopenia were involved in our study and their liver function indexes, prothrombin activity, antiplatelet antibody and bone marrow biopsy results were retrospectively analyzed.Results The decrease of the platelet number was not in proportion to the degree of cirrhosis in the eight patients with cirrhosis developed thrombocytopenia, out of proportion to their liver disease.They were diagnosed as immune thrombocytopenia (ITP) based on positive anti-platelet antibody and exclusion of severe infection, disseminated intravascular coagulation, aplastic anemia, lymphoma, thrombotic thrombocytopenic purpura et al.The number of platelet obviously increased with the treatment of immunoglobulin and corticosteroids.Conclusion Immune thrombocytopenia must be considered and treated in the post-hepatitic cirrhosis patients when the platelets decreased markedly in a short-term.
- thrombocytopenia /
- autoimmune diseases /
- hepatitis /
- viral

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参考文献(15)

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