肝癌肝移植的临床及基础研究

万钧; 范上达

肝癌肝移植的临床及基础研究

万钧,
范上达

香港大学李嘉诚医学院外科学系

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2012-04-20

Clinical and basic research on liver transplantation for hepatocellular carcinoma

摘要

摘要: <正>肝移植是对于肝癌最为有效的治疗方式。因为其可以根除肿瘤主体及镜下微小肿瘤病灶并提供给患者一个具备良好功能的肝脏。如今肝移植治疗小肝癌的5年成活率已经高达80%。但是由于肝移植手术仅能提供给一些本就预期预后良好的肝癌初期患者,所以只有小部分符合条件的肝癌患者能够受惠
- 肝肿瘤 /
- 肝移植
- liver neoplasms /
- liver transplantation

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参考文献(11)

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[2]Fan ST, Poon RT, Yeung C, et al.Outcome after partial hep-atectomy for hepatocellular cancer within the Milan criteria[J].Br J Surg, 2011, 98 (9) :1292-1300.

[3]Zheng SS, Xu X, Wu J, et al.Liver transplantation for hepa-tocellular carcinoma:Hangzhou experiences[J].Transplan-tation, 2008, 85 (12) :1726-1732.

[4]Fan ST, Lo CM, Poon RT, et al.Continuous improvement ofsurvival outcomes of resection of hepatocellular carcinoma:a 20-year experience[J].Ann Surg, 2011, 253 (4) :745-758.

[5]Gordon-Weeks AN, Snaith A, Petrinic T, et al.Systematicreview of outcome of downstaging hepatocellular cancer be-fore transplantation in patients outside the Milan criteria[J].Br J Surg, 2011, 98 (9) :1201-1208.

[6]Lo CM, Fan ST, Liu CL, et al.Living donor versus deceaseddonor liver transplantation for early irresectable hepatocellularcarcinoma[J].Br J Surg, 2007, 94 (1) :78-86.

[7]Man K, Lo CM, Xiao JW, et al.The significance of acutephase small-for-size graft injury on tumor growth and inva-siveness after liver transplantation[J].Ann Surg, 2008, 247 (6) :1049-1057.

[8]Man K, Ng KT, Lo CM, et al.Ischemia-reperfusion ofsmall liver remnant promotes liver tumor growth and metas-tases-activation of cell invasion and migration pathways[J].Liver Transpl, 2007, 13 (12) :1669-1677.

[9]Shih KC, Man K.Small-for-size liver graft injury-impacton tumor behavior[J].Transplant Rev (Orlando) , 2010, 24 (1) :1-10.

[10]Man K, Shih KC, Ng KT, et al.Molecular signature linked toacute phase injury and tumor invasiveness in small-for-size liver grafts[J].Ann Surg, 2010, 251 (6) :1154-1161.

[11]Cheng Q, Ng KT, Fan ST, et al.Distinct mechanism of small-for-size fatty liver graft injury--Wnt4 signaling activateshepatic stellate cells[J].Am J Transplant, 2010, 10 (5) :1178-1188.

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