甲胎蛋白应答在肝细胞癌治疗中的预后价值

贾佳; 祁兴顺; 韩国宏

doi:10.3969/j.issn.1001-5256.2013.08.006

甲胎蛋白应答在肝细胞癌治疗中的预后价值

DOI: 10.3969/j.issn.1001-5256.2013.08.006

第四军医大学西京消化病医院消化介入科

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中图分类号: R735.7
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出版历程
- 收稿日期: 2013-03-13
- 出版日期: 2013-08-20

Prognostic value of α-fetoprotein response in treatment of hepatocellular carcinoma

摘要

摘要:
肝细胞癌(HCC)是最常见的肝脏恶性肿瘤。因其恶性程度高、预后差,准确评估患者的治疗效果及预后情况至关重要。尽管目前影像学是肝癌预后评估的标准方法,但其仍存在诸多局限性。甲胎蛋白是重要的肝癌肿瘤标志物,广泛的应用于肝癌的筛查、诊断及预后评价。总结了甲胎蛋白应答在评判肝癌患者预后的相关文献。整体上,甲胎蛋白应答在肝癌患者接受射频消融、肝动脉化疗栓塞、钇90放射性栓塞、索拉菲尼等分子靶向药物、全身化疗、肝动脉灌注化疗或同步放化疗等治疗后具有良好的预后价值。
- 癌,肝细胞 /
- 甲胎蛋白类 /
- 预后
Abstract:
Primary hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver.Accurate assessment of treatment outcome and prognosis in HCC patients is very important due to its high malignancy and poor prognosis.Currently, radiological imaging, though a standard method for prognostic evaluation of HCC, has a lot of limitations.As an important serological marker of HCC, alpha-fetoprotein (AFP) has been widely used in the screening, diagnosis, and prognostic evaluation of HCC.The studies regarding the prognostic value of AFP response in HCC patients were summarized.Generally, AFP has good prognostic value in HCC patients treated with radiofrequency ablation, transarterial chemoembolization, yttrium-90 radioembolization, molecular targeted agents like sorafenib, systemic chemotherapy, hepatic artery infusion chemotherapy, or concurrent chemoradiotherapy.
- carcinoma /
- hepatocellular /
- alpha-fetoproteins

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参考文献(31)

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