氧化应激、线粒体通透性转换与肝衰竭的相关性

王克菲; 朱跃科; 孟庆华

doi:10.3969/j.issn.1001-5256.2013.09.021

氧化应激、线粒体通透性转换与肝衰竭的相关性

DOI: 10.3969/j.issn.1001-5256.2013.09.021

首都医科大学附属北京佑安医院重疾肝病科

基金项目:

首都卫生发展科研专项项目(2011-2018-09)；北京市教育委员会科研计划项目(11320098)；北京市自然科学基金资助项目(7112064)；

详细信息

中图分类号: R575.3
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出版历程
- 收稿日期: 2013-03-21
- 出版日期: 2013-09-20

Research advances in oxidative stress and mitochondrial permeability transition in liver failure

Beijing Youan Hospital, Capital Medical University

Research funding:

摘要

摘要: 目前治疗肝衰竭的主要手段有内科综合治疗、人工肝治疗、肝移植和干细胞移植治疗,虽然取得了较好的疗效,但是仍然有一部分患者由于病情凶险及治疗时机延误而最终死亡。氧化应激损伤是近年来研究的热点,抗氧化治疗也越来越受到关注。综合近年来的研究成果,对氧化应激损伤、线粒体膜通透性转换孔(MPTP)线粒体膜通透性转换孔及其与肝衰竭疾病的相关性做综述,阐明氧化应激损伤在肝衰竭发病中的重要性,为今后的进一步抗氧化治疗提供理论依据及思路。
- 肝功能衰竭 /
- 线粒体膜 /
- 氧化性应激
Abstract: Major treatment options for liver failure include clinical medical treatment, and prevention of complications) , artificial liver, liver transplantation, and stem cell transplantation. While these means are known to have produced favorable outcomes, some patients died due to acute and severe onset of disease or treatment delays. Oxidative stress has emerged as a research hotspot in recent years and antioxidant treatment has been drawing increasing attention. Outlines research developments in recent years and reviews the association of oxidative stress injury and mitochondrial permeability transition pore ( MPTP) with liver failure, in an effort to shed light on the importance of oxidative stress in the pathogenesis of liver failure and offer a theoretical basis and ideas for antioxidant therapy in the future.
- liver failure /
- mitochondrial membranes /
- oxidative stress

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参考文献(48)

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