非酒精性脂肪性肝病的发病机制

姜煜资; 聂红明; 汪蓉

doi:10.3969/j.issn.1001-5256.2019.11.044

非酒精性脂肪性肝病的发病机制

DOI: 10.3969/j.issn.1001-5256.2019.11.044

1. 上海中医药大学附属曙光医院肝病科
2. 上海市浦东新区中医医院病理科

基金项目:

国家中管局第六批全国老中医药专家学术经验继承工作项目资助(国中医药人教发(2017)29号文)；上海市中医药事业发展三年行动计划(2018年-2020年)治未病服务产品和技术项目(ZY(2018-2020)-ZWB-1001-CPJS25)；浦东新区中医药研发与创新专项(PDZYYFCX-201813)；

详细信息

中图分类号: R575.5
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出版历程
- 收稿日期: 2019-06-11
- 出版日期: 2019-11-20

Research advances in the pathogenesis of nonalcoholic fatty liver disease

Department of Hepatology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 非酒精性脂肪性肝病是导致慢性肝功能障碍的最常见原因,其发病机制与进展过程复杂。随着研究的深入,"多重打击"学说已逐渐替代了经典的"二次打击"学说。包括神经内分泌免疫炎症网络在内的"多重打击"学说认为,胰岛素抵抗、脂肪组织功能障碍、线粒体功能障碍、内质网应激、炎症激活、脂肪酸、肠道菌群、铁超载、饮食因素以及遗传和表观遗传因素等均参与NAFLD的疾病进展。结合近年的研究进展,重点从遗传与表观遗传因素、肠道菌群、肝内免疫细胞、水通道蛋白等方面对NAFLD的发病机制进行了综述。
- 非酒精性脂肪性肝病 /
- 遗传 /
- 胃肠道微生物组 /
- 水通道蛋白
Abstract: Nonalcoholic fatty liver disease( NAFLD) is the leading cause of chronic liver dysfunction and has complex pathogenesis and progression. With in-depth studies in recent years,the theory of“two hits”has gradually been replaced by the theory of“multiple hits”. The theory of“multiple hits”including the neuroendocrine immune inflammatory network suggests that various factors participate in the progression of NAFLD,such as insulin resistance,adipose tissue dysfunction,mitochondrial dysfunction,endoplasmic reticulum stress,inflammatory activation,fatty acids,gut microbiota,iron overload,dietary factors,genetic factors,and epigenetic factors. With reference to the research advances in recent years,this article reviews the pathogenesis of NAFLD from the aspects of genetic and epigenetic factors,gut microbiota,intrahepatic immune cells,and aquaporin.
- non-alcoholic fatty liver disease /
- heredity /
- gastrointestinal microbiome /
- aquaporin

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参考文献(25)

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