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Volume 41 Issue 8
Aug.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(8): 1700-1707

Mechanism of the nuclear factor-kappa B signaling pathway regulating ferroptosis and its role in liver diseases

DOI: 10.12449/JCH250835
  • 1.

    The Second Clinical Medical College Henan University of Chinese Medicine，Zhengzhou 450046，China

  • 2.

    Institute of Hepatology Henan University of Chinese Medicine，Zhengzhou 450046，China

Research funding:

The Special Research Project of Traditional Chinese Medicine in Henan Province (2022ZY1167);

The Special Research Project of Traditional Chinese Medicine in Henan Province (2024ZY2156);

National Famous Traditional Chinese Medicine Practitioner Inheritance Workshop Construction Project (National Chinese Medicine Office Human Education Letter ［2018］ No.119)

More Information
  • Corresponding author: LU Baoping， lbp1921@sohu.com （ORCID： 0000-0002-3707-2185）
  • Received Date: 2024-11-25
  • Accepted Date: 2025-01-07
  • Published Date: 2025-08-25
    Abstract
  • As a classical inflammatory response pathway， the nuclear factor-kappa B （NF-κB） signaling pathway plays a critical role in various physiological and pathological processes. Ferroptosis is a new form of non-apoptotic cell death， and recent studies have shown that there is a strong link between the NF-κB signaling pathway and ferroptosis， which affects the development and progression of liver diseases. Therefore， regulation of ferroptosis by targeting the NF-κB signaling pathway has a great potential in the treatment of liver diseases. This article discusses the influence of the NF-κB signaling pathway on the critical links such as lipid metabolism and iron metabolism during ferroptosis， as well as its mechanism of action in the positive and negative regulation of ferroptosis. Meanwhile， this article reviews the research advances in the role of this signaling pathway in liver diseases such as liver injury， nonalcoholic fatty liver disease， alcoholic liver disease， and hepatocellular carcinoma through the regulation of ferroptosis， so as to provide a reference for further understanding of the pathogenesis of liver diseases and the development of new therapeutic strategies.

     

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