中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 1
Jan.  2014
Turn off MathJax
Article Contents

Effects of sex hormones on stem cells and stem cell therapy for liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2014.01.024
  • Received Date: 2013-03-07
  • Published Date: 2014-01-20
  • Substantial progress has been made in the stem cell therapy for liver fibrosis. However, the therapeutic effect is limited by decreased self- renewal of stem cells during migration. Therefore, to improve the self- renewal of stem cells after transplantation is urgent and essential for the successful application of stem cells in clinical practice. Current studies have shown that sex hormones have an impact on the self- renewal of stem cells. The effects of estrogens and androgens on the self- renewal of various stem cells and the functional differences between the stem cells from persons of different sexes are reviewed. Moreover, the effect of sex hormones on stem cell therapy for liver fibrosis is discussed. It is considered that sex hormones have significant theoretical and clinical values for improving the self- renewal of stem cells and selecting appropriate stem cells in the stem cell therapy for liver fibrosis.

     

  • loading
  • [1]HUANG T, LIU YX, DONG CF, et al.Virtual touch tissue imaging and quantification for hepatic fibrosis in patients with chronic liver diseases[J/CD].Chin J Exp Clin Infect Dis:Electronic Edition, 2012, 6 (4) :283-287. (in Chinese) 黄婷, 刘映霞, 董常峰, 等.声触诊组织成像与量化技术评价慢性肝病肝纤维化分期的研究[J/CD].中华实验和临床感染病杂志:电子版, 2012, 6 (4) :283-287.
    [2]QIN HM.Molecular mechanism research on BMSCs in the effect of liver fibrosis[J].China Med Herald, 2013, 10 (4) :20-21, 24. (in Chinese) 覃慧敏.BMSCs作用于肝纤维化的分子机制研究[J].中国医药导报, 2013, 10 (4) :20-21, 24.
    [3] AHMAD A, AHMAD R.Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches[J].Saudi J Gastroenterol, 2012, 18 (3) :155-167.
    [4]CHRIST B, STOCK P.Mesenchymal stem cell-derived hepatocytes for functional liver replacement[J].Front Immunol, 2012, 3:168.
    [5]ZHANG LT, WANG S, LI JF, et al.Effect of hurnan bone marrow mesenchymal stem cell supernatant a proliferation cycle and MMP-1 expression of hepatic stellate cells[J].J Clin Hepatol, 2012, 11 (28) :836-838. (in Chinese) 张立婷, 王珊, 李俊峰, 等.人骨髓间充质干细胞上清液对体外肝星状细胞增殖周期及MMP-1表达的影响[J].临床肝胆病杂志, 2012, 11 (28) :836-838.
    [6] XU H, QIAN H, ZHU W, et al.Mesenchymal stem cells relieve fibrosis of Schistosoma japonicum-induced mouse liver injury[J].Exp Biol Med (Maywood) , 2012, 237 (5) :585-592.
    [7]BURT RK, LOH Y, PEARCE W, et al.Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases[J].JAMA, 2008, 299 (8) :925-936.
    [8]TOMA C, WAGNER WR, BOWRY S, et al.Fate of culture-expanded mesenchymal stem cells in the microvasculature:in vivo observations of cell kinetics[J].Circ Res, 2009, 104 (3) :398-402.
    [9]SEKIGUCHI H, II M, JUJO K, et al.Estradiol promotes neural stem cell differentiation into endothelial lineage and angiogenesis in injured peripheral nerve[J].Angiogenesis, 2013, 16 (1) :45-58.
    [10] YOSHIKAWA T, SAMATA B, OGURA A, et al.Systemic administration of valproic acid and zonisamide promotes differentiation of induced pluripotent stem cell-derived dopaminergic neurons[J].Front Cell Neurosci, 2013, 7:11.
    [11]ERWIN GS, CRISOSTOMO PR, WANG Y, et al.Estradiol-treated mesenchymal stem cells improve myocardial recovery after ischemia[J].J Surg Res, 2009, 152 (2) :319-324.
    [12]CHEN HY, ZHANG X, CHEN SF, et al.The protective effect of17beta-estradiol against hydrogen peroxide-induced apoptosis on mesenchymal stem cell[J].Biomed Pharmacother, 2012, 66 (1) :57-63.
    [13] LI HQ, ZHAO Q, ZHU D, et al.Transplantation of bone marrowderived endothelial progenitor cells preconditioned with ex vivo17beta-estradiol enhances healing efficacy after acute myocardial infarction[J].Chin J Cardiol, 2011, 39 (5) :420-423. (in Chinese) 李海清, 赵强, 朱丹, 等.17β-雌二醇预处理的骨髓源性内皮祖细胞治疗急性心肌梗死的实验研究[J].中华心血管病杂志, 2013, 39 (5) :420-423.
    [14]CHEN FP, HU CH, WANG KC.Estrogen modulates osteogenic activity and estrogen receptor mRNA in mesenchymal stem cells of women[J].Climacteric, 2013, 16 (1) :154-160.
    [15]ZHANG M, CHEN FM, WANG AH, et al.Estrogen and its receptor enhance mechanobiological effects in compressed bone mesenchymal stem cells[J].Cells Tissues Organs, 2012, 195 (5) :400-413.
    [16]MAXIMOV PY, LEWIS-WAMBI JS, JORDAN VC.The paradox of oestradiol-Induced breast cancer cell growth and apoptosis[J].Curr Signal Transduct Ther, 2009, 4 (2) :88-102.
    [17]ACCONCIA F, BOCEDI A, ASCENZI P.Does palmitoylation target estrogen receptors to plasma membrane caveolae?[J].IUBMB Life, 2003, 55 (1) :33-35.
    [18]YUN SP, LEE MY, RYU JM, et al.Role of HIF-1alpha and VEGF in human mesenchymal stem cell proliferation by 17betaestradiol:involvement of PKC, PI3K/Akt, and MAPKs[J].Am J Physiol Cell Physiol, 2009, 296 (2) :c317-c326.
    [19]BRONZI D, BRAMANTI V, TOMASSONI D, et al.Neural markers expression in rat bone marrow mesenchymal stem cell cultures treated with neurosteroids[J].Neurochem Res, 2010, 35 (12) :2154-2160.
    [20]YUN SP, RYU JM, KIM MO, et al.Rapid actions of plasma membrane estrogen receptors regulate motility of mouse embryonic stem cells through a profilin-1/cofilin-1-directed kinase signaling pathway[J].Mol Endocrinol, 2012, 26 (8) :1291-1303.
    [21]YUNE TY, PARK HG, LEE JY, et al.Estrogen-induced Bcl-2expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation[J].J Neurotrauma, 2008, 25 (9) :1121-1131.
    [22]AYALOGLU-BUTUN F, TERZIOGLU-KARA E, TOKCAERKESKIN Z, et al.The effect of estrogen on bone marrow-derived rat mesenchymal stem cell maintenance:inhibiting apoptosis through the expression of Bcl-xL and Bcl-2[J].Stem Cell Rev, 2012, 8 (2) :393-401.
    [23]CHANG CY, HSUUW YD, HUANG FJ, et al.Androgenic and antiandrogenic effects and expression of androgen receptor in mouse embryonic stem cells[J].Fertil Steril, 2006, 85 (Suppl 1) :1195-1203.
    [24]LESKELA HV, OLKKU A, LEHTONEN S, et al.Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts[J].Bone, 2006, 39 (5) :1026-1034.
    [25]FLORVAAG A, OBERLE V, FRITZENWANGER M, et al.Testosterone deficiency in male heart failure patients and its effect on endothelial progenitor cells[J].Aging Male, 2012, 15 (3) :180-186.
    [26]RAY R, HERRING CM, MARKEL TA, et al.Deleterious effects of endogenous and exogenous testosterone on mesenchymal stem cell VEGF production[J].Am J Physiol Regul Integr Comp Physiol, 2008, 294 (5) :1498-1503.
    [27]HUANG CK, TSAI MY, LUO J, et al.Suppression of androgen receptor enhances the self-renewal of mesenchymal stem cells through elevated expression of EGFR[J].Biochim Biophys Acta, 2013, 1833 (5) :1222-1234.
    [28] KOLF CM, CHO E, TUAN RS.Mesenchymal stromal cells.Biology of adult mesenchymal stem cells:regulation of niche, self-renewal and differentiation[J].Arthritis Res Ther, 2007, 9 (1) :204.
    [29]CRISOSTOMO PR, WANG M, HERRING CM, et al.Sex dimorphisms in activated mesenchymal stem cell function[J].Shock, 2006, 26 (6) :571-574.
    [30]CRISOSTOMO PR, WANG M, HERRING CM, et al.Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression:role of the 55 kDa TNF receptor (TNFR1) [J].J Mol Cell Cardiol, 2007, 42 (1) :142-149.
    [31]CRISOSTOMO PR, MARKEL TA, WANG M, et al.In the adult mesenchymal stem cell population, source gender is a biologically relevant aspect of protective power[J].Surgery, 2007, 142 (2) :215-221.
    [32]MAO W.RE:higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males[J].Hepatology, 2012, 56 (5) :2008.
    [33]HUANG CK, LEE SO, LAI KP, et al.Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis[J].Hepatology, 2013, 57 (4) :1550-1563.
    [34]ZHANG B, WU ZY.Estrogen derivatives:novel therapeutic agents for liver cirrhosis and portal hypertension[J].Eur J Gastroenterol Hepatol, 2013, 25 (3) :263-270.
    [35]SAKAMOTO M, NAKAMURA T, TORIMURA T, et al.Transplantation of endothelial progenitor cells ameliorates vascular dysfunction and portal hypertension in carbon tetrachloride-induced rat liver cirrhotic model[J].J Gastroenterol Hepatol, 2013, 28 (1) :168-178.
    [36]ZHOU W, CHEN PF, WU XL, et al.Effect of bone marrow mesenchymal stem cells on experimental liver fibrosis in rats and relevant mechanism[J].Chin J Biologicals, 2012, 25 (2) :176-180. (in Chinese) 周伟, 陈鹏飞, 吴小翎, 等.骨髓间充质干细胞对实验性肝纤维化大鼠的作用及其机制[J].中国生物制品学杂志, 2012, 25 (2) :176-180.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2631) PDF downloads(594) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return