中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2016
Turn off MathJax
Article Contents

Research advances in the pathogenesis of drug-induced liver injury

DOI: 10.3969/j.issn.1001-5256.2016.02.041
Research funding:

 

  • Received Date: 2015-06-19
  • Published Date: 2016-02-20
  • In recent years,with an increasing number of drug types and unreasonable drug use,the incidence and mortality of drug- induced liver injury( DILI) have been increasing. The pathogenesis of DILI is complex,and may involve liver injury caused by the direct effect of drugs,immune- mediated liver injury,mitochondrial injury,and bile duct injury,etc. This article investigates the pathogenesis and its important role in the prevention and treatment of DILI,and reviews the research advances in the pathogenesis of DILI.

     

  • loading
  • [1]XU JM.Recommendations for the diagnosis and treatment of acute drug-induced liver injury(draft)[J].Chin J Dig,2007,27(11):765-767.(in Chinese)许建明.急性药物性肝损伤诊治建议(草案)[J].中华消化杂志,2007,27(11):765-767.
    [2]REN DD,DENG CL.Research advances in drug-induced liver injury[J].J Military Surg Southwest China,2014,16(6):670-672.(in Chinese)任东东,邓存良.药物性肝损伤的研究进展[J].西南军医,2014,16(6):670-672.
    [3]SHI ZY,WANG WM,DENG SH.Primary culture and identification of cardiomyocytes of neonatal SD rats[J].Acta Univ Med Anhui,2014,49(1):122-124.(in Chinese)时兆燕,汪伟民,邓松华.还原型谷胱甘肽联合腺苷蛋氨酸治疗化疗药物性肝损害的临床疗效[J].安徽医科大学学报,2014,49(1):122-124.
    [4]ZHANG S,XIONG ZF.The research progrssion of DILD[J].Med J Chin People's Health,2013,25(1):87-91,121.(in Chinese)张盛,熊枝繁.药物性肝病的研究进展[J].中国民康医学,2013,25(1):87-91,121.
    [5]LIU XY,CHEN J,WANG XX,et al.Etiology of acute,subacute,and acute-on-chronic liver failure:an analysis of 323 cases[J].Clin Med Engineer,2012,19(5):823-825.(in Chinese)刘晓燕,陈婧,王晓霞,等.323例急性、亚急性、慢加急性肝衰竭病因特点分析[J].临床医学工程,2012,19(5):823-825.
    [6]LIANG B,YU GM,MAO J.Research advances in drug-induced hepatitis and related therapeutic methods[J].Pharm J Chin PLA,2011,27(2):175-177,188.(in Chinese)梁斌,余国梅,毛静.药物性肝炎及其治疗的研究进展[J].解放军药学学报,2011,27(2):175-177,188.
    [7]VINKEN M,MAES M,VANHAECKE T,et al.Drug-induced liver injury:mechanisms,types and biomarkers[J].Curr Med Chem,2013,20(24):3011-3021.
    [8]TENG GJ,SUN Y,CHANG BX,et al.Pathogenic mechanism and influencing factors of drug-induced liver injury[J].Chin Hepatol,2012,16(6):497-500.(in Chinese)藤光菊,孙颖,常彬霞,等.药物性肝损伤的致病机制及影响因素[J].肝脏,2012,16(6):497-500.
    [9]PARK K,WILLIAMS DP,NAISBITT DJ,et al.Investigation of toxic metabolites during drug development[J].Toxicol Appl Pharmacol,2005,207(2 Suppl):425-434.
    [10]JAESCHKE H,WILLIAMS CD,RAMACHANDRAN A,et al.Acetaminophen hepatotoxicity and repair:the role of sterile inflammation and innate immunity[J].Liver Int,2012,32(1):8-20.
    [11]KHANDELWAL N,JAMES LP,SANDERS C,et al.Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure[J].Hepatology,2011,53(2):567-576.
    [12]SZABO G,MANDREKAR P,DOLGANIUC A.Innate immune response and hepatic inflammation[J].Semin Liver Dis,2007,27(4):339-350.
    [13]FISHER JE,MCKENZIE TJ,LILLEGARD JB,et al.Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure[J].J Surg Res,2013,180(1):147-155.
    [14]KUBES P,MEHAL WZ.Sterile inflammation in the liver[J].Gastroenterology,2012,143(5):1158-1172.
    [15]LIU ZX,GOVINDARAJAN S,OKAMOTO S,et al.NK cells cause liver injury and facilitate the induction of T cell mediated immunity to a viral liver infection[J].J Immunol,2000,164(12):6480-6486.
    [16]MARTIN-MURPHY BV,KOMINSKY DJ,ORLICKY DJ,et al.Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury[J].Hepatology,2013,57(4):1575-1584.
    [17]LU BP,YANG XN,XU JY.Effect of Baogan Jiedu Granule on IL-18 and cell apoptosis in model mice with acute liver injury induced by tetracycline[J].J Henan Univ Chin Med,2006,1(1):26-28.(in Chinese)禄保平,杨晓娜,许家艳.保肝解毒颗粒对四环素所致急性肝损伤小鼠IL-18及细胞凋亡的影响[J].河南中医学院学报,2006,1(1):26-28.
    [18]ANDRADE RJ,LUCENA MI,ALONSO A,et al.HLA class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease[J].Hepatology,2004,39(6):1603-1612.
    [19]SCHNYDER B,BURKHART C,SCHNYDER-FRUTIG K,et al.Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+T cells from allergic individuals[J].J Immunol,2000,164(12):6647-6654.
    [20]CHEN HW,CHIEN CT,YU SL,et al.Cyclosporine A regulate oxidative stress-induced apoptosis in cardiomyocytes:mechanisms via ROS generation,iN OS and Hsp70[J].Br J Pharmacol,2002,137(6):771-781.
    [21]ANDREWS E,ARMSTRONG M,TUGWOOD J,et al.A role for the pregnane X receptor in flucloxacillin-induced liver injury[J].Hepatology,2010,51(5):1656-1664.
    [22]STEPHENS C,LPEZ-NEVOT M,RUIZ-CABELLO F,et al.HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity[J].PLoS One,2013,8(7):e68111.
    [23]VUILLEUMIER N,ROSSIER MF,CHIAPPE A,et al.CYP2E1genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis[J].Eur J Clin Pharmacol,2006,62(6):423-429.
    [24]TANG N,DENG R,WANG Y,et al.GSTM1 and GSTT1 null polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury:a meta-analysis[J].Int J Tuberc Lung Dis,2013,17(1):17-25.
    [25]STAPELBROEK JM,VAN ERPECUM KJ,KLOMP LW,et al.Liver disease associated with canalicular transport defects:current and future therapies[J].J Hepatol,2010,52(2):258-271.
    [26]PESSAYRE D,FROMENTY B,BERSON A,et al.Central role of mitochondria in drug-induced liver injury[J].Drug Metab Rev,2012,44(1):34-87.
    [27]AU JS,NAVARRO VJ,ROSSI S.Review article:Drug-induced liver injury-its pathophysiology and evolving diagnostic tools[J].Aliment Pharmacol Ther,2011,34(1):11-20.
    [28]MCGILL MR,SHARPE MR,WILLIAMS CD,et al.The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation[J].J Clin Invest,2012,122(4):1574-1583.
    [29]HONDA HM,KORGE P,WEISS JN.Mitochondria and ischemia/reperfusion injury[J].Ann N Y Acad Sci,2005,1047(1):248-258.
    [30]AN J,MEHRHOF F,HARMS C,et al.ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis[J].J Hepatol,2013,58(2):297-305.
    [31]GRATTAGLIANO I,BONFRATE L,DIOGO CV,et al.Biochemical mechanisms in drug-induced liver injury:certainties and doubts[J].World J Gastroenterol,2009,15(39):4865-4876.
    [32]LUCENA MI,GARA-MARTN E,ANDRADE RJ,et al.Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury[J].Hepatology,2010,52(1):303-312.
    [33]LI MK,CRAWFORD JM.The pathology of cholestasis[J].Semin Liver Dis,2004,24(1):21-42.
    [34]MORGAN RE,TRAUNER M,VAN STADEN CJ,et al.Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development[J].Toxicol Sci,2010,118(2):485-500.
    [35]PAULI-MAGNUS C,MEIER PJ,STIEGER B.Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy[J].Semin Liver Dis,2010,30(2):147-159.
    [36]MING YN,LIU XL,MAO YM.The pathogenesis of drug-induced liver injury(DILI)[J].J Pract Hepatol,2014,17(6):657-660.(in Chinese)明雅南,刘晓琳,茅益民.药物性肝损伤发病机制研究进展[J].实用肝脏病杂志,2014,17(6):657-660.
    [37]RAMACHANDRAN A,MCGILL MR,XIE Y,et al.Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice[J].Hepatology,2013,58(6):2099-2108.
    [38]KAPLOWITZ N,SHINOHARA M,LIU ZX,et al.How to protect against acetaminophen:don't ask for JUNK[J].Gastroenterology,2008,135(4):1047-1051.
    [39]SHARMA M,GADANG V,JAESCHKE A.Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity[J].Mol Pharmacol,2012,82(5):1001-1007.
    [40]RAMACHANDRAN A,MCGILL MR,XIE Y,et al.Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice[J].Hepatology,2013,58(6):2099-2108.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2079) PDF downloads(489) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return