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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 7
Jul.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(7): 1724-1728

Role of microRNA-122 in the development, progression, and diagnosis of liver disease

DOI: 10.3969/j.issn.1001-5256.2021.07.052
  • 1.

    Graduate School, Guangxi University of Chinese Medicine, Nanning 530001, China

  • 2a.

    Department of Infectious Diseases, Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning 530001, China

  • 2b.

    Department of Science and Technology, Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning 530001, China

  • 2c.

    Department of Gastroenterology, Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning 530001, China

  • 3.

    Department of Endocrinology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530001, China

Research funding:

National Natural Science Foundation of China (81860790);

Guangxi Natural Science Foundation of China (2017GXNSFAA198183)

  • Received Date: 2020-12-03
  • Accepted Date: 2020-12-25
  • Published Date: 2021-07-20
    Abstract
  • MicroRNA is a type of small non-coding RNA that participates in multiple links such as cell proliferation and apoptosis by regulating gene expression after transcription. More and more studies have shown that microRNA-122 (miRNA-122) is involved in the development and progression of a variety of liver diseases. With reference to related reports in the literature, this article summarizes advances in the role of miRNA-122 in various liver diseases including nonalcoholic fatty liver disease, hepatitis, liver fibrosis, and liver cancer and analyzes the potential of miRNA-122 as a new noninvasive biomarker, so as to provide a reference for exploring the diagnosis and treatment of liver disease.

     

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