Clinical features of chronic liver disease with autoimmune blood diseases and the clinical effect of glucocorticoid

Long LIU; Yao LIU; Fangyuan GAO; Xianbo WANG

doi:10.3969/j.issn.1001-5256.2021.08.025

Volume 37 Issue 8

Aug. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(8): 1878-1882

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Clinical features of chronic liver disease with autoimmune blood diseases and the clinical effect of glucocorticoid

DOI: 10.3969/j.issn.1001-5256.2021.08.025

Department of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China

Research funding:

Capital's Funds for Health Improvement and Research (2018-1-2172);

Funded by Beijing Science and Technology Committee (Z191100006619033)

Received Date: 2021-03-04
Accepted Date: 2021-05-14
Published Date: 2021-08-20

Abstract

Abstract

Objective To investigate the clinical features of chronic liver disease with immune blood diseases and the clinical effect of glucocorticoid therapy. Methods A retrospective analysis was performed for the clinical data of 17 patients with chronic liver disease and immune blood diseases who were admitted to Beijing Ditan Hospital from January 2008 to December 2019, and according to the type of blood disease, they were divided into autoimmune hemolytic anemia (AIHA) group, immune thrombocytopenia (ITP) group, and Evans syndrome group. After glucocorticoid therapy and related treatment of liver disease, the three groups were compared in terms of clinical data and laboratory markers before and after treatment. The Mann-Whitney U test was used for comparison of continuous data between two groups. Results Among the 17 patients with chronic liver disease, 15 had no viral hepatitis, among whom 9 (52.9%) had autoimmune liver disease. Among these 17 patients, 6 had AIHA, 8 had ITP, and 3 had Evans syndrome. Glucocorticoid therapy was given for 13 patients, among whom12 achieved complete remission or partial remission, resulting in an overall response rate of 92.3%. After treatment, the ITP group had significant reductions in total bilirubin [35.8 (14.3-58.0) μmol/L vs 165.6 (21.3-374.3) μmol/L, Z=-2.205, P=0.027] and direct bilirubin [24.9 (7.0-43.3) μmol/L vs 121.9 (11.7-279.9) μmol/L, Z=-2.205, P=0.027], and the AIHA group had a significant increase in hemoglobin [94.0 (65.0-99.3) g/L vs 62.2 (42.3-80.5) g/L, Z=-2.242, P=0.025]. Conclusion Immune blood diseases are observed in patients with various types of chronic liver disease, among which autoimmune liver disease with immune blood diseases has a relatively high incidence rate. Glucocorticoid is a safe and effective therapeutic method for the treatment of chronic liver disease with immune blood diseases.
- Liver Diseases,
- Anemia, Hemolytic, Autoimmune,
- Purpura, Thrombocytopenic, Idiopathic,
- Evans Syndrome,
- Glucocorticoids

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Clinical features of chronic liver disease with autoimmune blood diseases and the clinical effect of glucocorticoid

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Clinical features of chronic liver disease with autoimmune blood diseases and the clinical effect of glucocorticoid

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