Expression mechanism and clinical significance of absent in melanoma 2 in liver diseases

Yingyu LE; Rongzhen ZHANG; Tingshuai WANG; Ningfang CHEN; Dewen MAO

doi:10.3969/j.issn.1001-5256.2021.10.049

Volume 37 Issue 10

Oct. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(10): 2488-2492

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Expression mechanism and clinical significance of absent in melanoma 2 in liver diseases

DOI: 10.3969/j.issn.1001-5256.2021.10.049

1.
Graduate School, Guangxi University of Chinese Medicine, Nanning 530222, China
2a.
First Ward of Liver Diseases, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
2b.
First Ward of Spleen and Stomach, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

General Project of National Natural Science Foundation of China (81774236);

National Natural Science Foundation of China (81960841);

Natural Science Foundation of Guangxi Province (2018GXNSFAA281096);

Guangxi Science and Technology Plan Project-Guangxi Science and Technology Base and Talent Special Project (GK AD17129001)

Received Date: 2021-03-03
Accepted Date: 2021-03-15
Published Date: 2021-10-20

Abstract

Abstract

Absent in melanoma 2 (AIM2) is a cytoplasmic double-stranded DNA (dsDNA) sensing protein that can recognize the dsDNA released during cell disturbance and pathogen invasion and trigger the activation of inflammasome cascade. Activation of inflammasomes leads to the maturation and release of inflammatory cytokines (interleukin-1β and interleukin-18), induces pyroptosis, and initiate innate immune response. Among these inflammasomes, AIM2 and its mechanism of action and clinical significance in liver diseases has become a research hotspot at present. This article summarizes and discusses the importance of AIM2 in the pathogenesis of various liver diseases including nonalcoholic fatty liver disease, hepatitis B virus infection, liver fibrosis, liver cirrhosis, and hepatocellular carcinoma, so as to provide new ideas and a reference for clinical treatment.
- Liver Diseases,
- Inflammation,
- Inflammasomes

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References(42)

References

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Expression mechanism and clinical significance of absent in melanoma 2 in liver diseases

DOI: 10.3969/j.issn.1001-5256.2021.10.049

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Expression mechanism and clinical significance of absent in melanoma 2 in liver diseases

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