Application of immune checkpoint inhibitors in liver transplantation for patients with hepatocellular carcinoma

Youcheng XIE; Shun CHEN; Chuyi LI; Ying ZHENG; Dong JIA; Jiucong ZHANG; Xiaohui YU

doi:10.3969/j.issn.1001-5256.2023.04.030

Volume 39 Issue 4

Apr. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(4): 941-947

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Application of immune checkpoint inhibitors in liver transplantation for patients with hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2023.04.030

Youcheng XIE^{1, 2},
Shun CHEN¹,
Chuyi LI¹,
Ying ZHENG¹,
Dong JIA^{1, 2},
Jiucong ZHANG¹,
Xiaohui YU^{1
,
,
,}

1.
Department of Gastroenterology, The 940 Hospital of Joint Service Support Force of the Chinese People's Liberation Army, Lanzhou 730050, China
2.
The First Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, China

Research funding:

Gansu Provincial Key R&D Program (20YF8FA099);

Gansu Provincial Youth Science and Technology Fund (20JR10RA016);

Gansu Provincial Clinical Medical Research Centre for Non-infectious Liver Diseases (21JR7RA017);

Scientific Research Plan of Gansu Provincial Health Commission (GSWSKY2021-047)

More Information

Corresponding author: YU Xiaohui, yuxiaohui@126.com (ORCID: 0000-0002-8633-3281)
Received Date: 2022-07-31
Accepted Date: 2022-09-18
Published Date: 2023-04-20

Abstract

Abstract

Liver transplantation, as one of the radical treatment strategies for hepatocellular carcinoma, has a good clinical effect in patients meeting the Milan criteria; however, the high recurrence rate and metastasis rate after surgery bring great challenges to the long-term survival of such patients. Therefore, how to improve long-term survival rate and reduce postoperative tumor metastasis has become a key problem that needs to be solved urgently. In recent years, immune checkpoint inhibitors (ICIs), with their good safety and objective reactivity, have provided a new opportunity for the treatment of patients with advanced liver cancer and have become potential candidates for improving the therapeutic effect of liver transplantation. At present, early clinical studies have reported the unique advantages of ICIs used alone or in combination in downstaging or bridging therapy before liver transplantation for hepatocellular carcinoma and adjuvant therapy after liver transplantation. Therefore, this article reviews the clinical trials of ICIs in liver transplantation for hepatocellular carcinoma and the advances in the application of ICIs in recent years and discuss its safety and efficacy, in order to provide a certain reference for clinical medication.
- Carcinoma, Hepatocellular,
- Liver Transplantation,
- Immunosuppressive Agents

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References(40)

References

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Application of immune checkpoint inhibitors in liver transplantation for patients with hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2023.04.030

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