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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 5
May  2023
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Article Contents

Research advances in acute pancreatitis-associated ascites fluid

DOI: 10.3969/j.issn.1001-5256.2023.05.035
Research funding:

National Clinical Key Subject of China (41732113)

More Information
  • Corresponding author: TANG Lijun, tanglj2016@163.com (ORCID: 0000-0001-6000-9515)
  • Received Date: 2022-08-23
  • Accepted Date: 2022-09-23
  • Published Date: 2023-05-20
  • Acute pancreatitis-associated ascites fluid (PAAF) is a common complication in patients with acute pancreatitis (AP) and is closely associated with the severity of AP, the development of local and systemic complications, and prognosis. PAAF may originate from the leakage of abdominal blood vessels, lymphatic vessels, and pancreatic duct. Recent studies have found that early removal of PAAF by abdominal paracentesis drainage can help to reduce systemic inflammation and alleviate pancreatitis-associated organ injury, thereby improving the conditions of patients with severe AP and reducing mortality. However, it is still not completely clear how PAAF aggravates systemic inflammatory response, participates in pancreatic injury and damage of distal organs, and leads to the aggravation of disease conditions in patients with AP. Therefore, this article gives an overview of PAAF and summarizes related studies in recent years, so as to provide directions for exploring the pathophysiological process and treatment of AP.

     

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