To investigate HCV genotypes and its clinical features in patients coinfected with HCV and HBV. HBV quantification and HCV genotypes were detected by sandwich hybidization on microplate.Serum marker of HBV and HCV were dectected using ELISA assay. Positive rates of HCV-RNA and HBV-DNA in patients with both HCV and HBV (72.51% and 30.41%) were lower than those with HCV or HBV alone (85.42% and 60.72%) . Frequency of type Ⅰ/1a and Ⅲ/2a in coinfection were higher than those in infection alone. Serum levels of ALT and TBil in Ⅱ/1b HCV-HBV coinfection were the highest and that of ALB and CHE were the lowest. Inhibition do exists between HCV and HBV although the syndrome of coinfection may more severe.
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