慢性乙型肝炎患者抗病毒治疗前后TRECs含量的变化

To quantitative analyze the T-cell receptor excision circles (TRECs) in chronic hepatitis B (CHB) patients before and after receiving interferon or adefovir dipivoxil.Quantitative detection of TRECs in peripheral blood mononuclear cells (PBMCs) from 27 normal individuals and 28 cases with CHB among which 15 cases treated with interferon and 13 cases with adefovir dipivoxil was performed by real-time fluorescence quantitative PCR.The mean value of TRECs in cases with CHB (7.29±2.26 copies/103 PBMCs) was lower than that in corresponding aged normal individuals (10.48±6.90 copies/103PBMCs) (P<0.05) .There was no statistical relationship between thymic output function and HBV DNA in CHB patients (r=0.06, P>0.05) .Interferon therapy increased the quantity of TRECs in CHB patients (12.77±5.25 vs 7.14±2.69 copies/103 PBMCs) (P<0.05) .There was no significant difference between the level of TRECs before and after adefovir dipivoxil treatment.The quantity of TRECs in CHB patients were lower than those in normal individuals.There was no significant relation between thymic output function and HBV DNA.The results indicated that interferon, but not adefovir dipivoxil, could increase the TRECs level in CHB patients.