Analysis of relationship of chronic severe hepatitis with hepatorenal syndrome

Objective To analyze the prevalence rate of hepatorenal syndrome among chronic severe hepatitis patients, to study changes of laboratory indicators and clinical condition and to discuss the relationship of hypoalbuminemia and hyponatremia with hepatorenal syndrome in patients with severe hepatitis.Methods 450 patients with severe hepatitis were enrolled.There were 105 patients with hepatorenal syndrome during hospitalization (HRS group) and 345 patients without hepatorenal syndrome (control group) .Child-pugh score, MELD, and prevalence rate of ascites among patients with and without hepatorenal syndrome was compared and difference of laboratory indicators were analyzed.Results Prevalence rate of hepatorenal syndrome among chronic severe hepatitis patients was 23.3%.MELD score among patients with hepatorenal syndrome was 31.7±4.5, which was higher than 26.3±6.8 among patients without hepatorenal syndrome (t=2.45, P<0.05) , prevalence rate of ascites was 100% in hepatorenal syndrome patients, which was higher than that (33.9%) in controls group (x2=140.65, P<0.01) .Albumin level among patients with hepatorenal syndrome was (27.3±3.2) g/L, which was lower than that (34.8±3.6) g/L among patients without hepatorenal syndrome (t=10.03, P<0.05) , sodium level was (128.5±7.5) mmol/L in HRS group, which was lower than that (137.4±6.5) mmol/L in controls group (t=4.72, P<0.01) .Total bilirubin, direct bilirubin, urea, creatine and potassium increased in patients with hepatorenal syndrome, however, total protein, albumin, sodium, chlorine decreased.Conclusion Hypoalbuminemia and hyponatremia are critical factors associated with the development of hepatorenl syndrome among patients with chronic severe hepatitis.