中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2011
Turn off MathJax
Article Contents

The application of bone marrow mesenchymal stem cells transplantation in liver regeneration

  • Published Date: 2011-09-20
  • With the development of modern medicine, stem cells with unlimited potential was gradually involved in various fields.The ability of self-renewal and multidirectional differentiation can offer replacement treatment for multiple diseases.In the end-stage of liver disease, with the reduction of liver cells and failure of liver function, liver function can be improved and liver fibrosis can be slowed or even reversed through the replacement therapy of stem cell.Stem cell therapy is expected to be the new technology for the replacement of liver transplantation.This review summarizes the general understanding of the therapeutic potentials of stem cells in liver disease, including the sources, mechanisms, and threapy methods of hepatic stem cells, and discusses some challenges for their therapeutic application.

     

  • loading
  • [1]Kisseleva T, Gigante E, Brenner DA.Recent advances in liv-er stem cell therapy[J].Curr Opin Gastroenterol, 2010, 26 (4) :395-402.
    [2]BasmaH, Soto-Gutierrez A, Yannam GR, et al.Differentia-tion and transplantation of human embryonic stem cell-de-rived hepatocytes[J].Gastroenterology, 2009, 136:990-999.
    [3] Gilchrist ES, Plevris JN. Bone marrow-derived stem cells in liver repair: 10 years down the line[J]. Liver Transpl, 2010, 16 (2) : 118-129.
    [4]Tajima F, Tsuchiya H, Nishikawa K, et al.Hepatocyte growthfactor mobilizes and recruits hematopoietic progenitor cells intoliver through astem cellfactor-mediatedmechanism[J].Hep-atol Res, 2010, 40 (7) :711-719.
    [5]Aurich H, SgoddaM, Kaltwasser P, et al.Hepatocyte differ-entiation of mesenchymal stem cells from human adipose tis-sue in vitro promotes hepatic integration in vivo[J].Gut, 2009, 58 (4) :570-581.
    [6]Yagi H, Parekkadan B, Suganuma K, et al.Long-term su-perior performance of a stem cell/hepatocyte device for thetreatment of acute liver failure[J].Tissue Eng Part A, 2009, 15 (11) :3377-3388.
    [7]Banas A, Teratani T, Yamamoto Y, et al.Rapid hepatic fatespecification of adipose-derived stem cells and their thera-peutic potential for liver failure[J].J Gastroenterol Hepatol, 2009, 24 (1) :70-77.
    [8]Kharaziha P, Hellstrim PM, Noorinayer B, et al.Improve-ment of liver function in liver cirrhosis patients after autolo-gous mesenchymal stem cell injection:a phase I-II clinicaltrial[J].Eur J Gastroenterol Hepatol, 2009, 21 (10) :1199-1205.
    [9] Ramasamy R, Lam EW, Soeiro I, et al. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth[J]. Leukemia, 2007, 21 (2) : 3040-310.
    [10]Alberti E, Los M, GarciaR, et al.Prolonged survival and ex-pression of neural markers by bone marrow derived stemcells transplanted into brain lesions[J].Med Sci Munit, 2009, 15 (2) :BR47-54.
    [11]Hu J, Feng K, Liu X, et al.Chondrogenic and osteogenicdifferentiations of human bone marrow-derived mesenchy-ma1 stem cells on ananofibrous scaffold with designed porenetwork[J].Biomaterials, 2009, 30 (28) :5061-5067.
    [12]Chivu M, Dima SO, Stancu CI, et al.In vitro hepatic differ-entiation of human bone marrow mesenchymal stem cellsunder differential exposure to liver specific factors[J].TranslRes, 2009, 154 (3) :122-132.
    [13]Bonora-Centelles A, Jover R, Mirabet V, et al.Sequentialhepatogenic trans-diferentiation of adipose tissue-derivedstem cells:relevance of different extracellular signaling mole-cules, transcription factors involved and expression of newkey marker genes[J].Cell Transplant, 2009, 18 (12) :1319-1340.
    [14] Quintana-Bustamante O, Alvarez-Barrientos A, Kofman AV, et al. Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion[J]. Hepatology, 2006, 43 (1) : 108-116.
    [15]Sato Y, Araki H, Kato J, et al.Human mesenchymal stemcells xenografted directly to rat liver are differentiated into hu-man hepatocytes without fusion[J].Blood, 2005, 106 (2) :756-763.
    [16]Van Poll D, Parekkadan B, Cho CH, et al.Mesenchymalstem cell-derived molecules directly modulate hepatocellu-lar death and regeneration in vitro and in vivo[J].Hepatolo-gy, 2008, 47 (5) :1634-1643.
    [17] Kuo TK, Hung SP, Chuang CH, et al. Stem cell therapy in liver disease: parameters governing the success of using bone marrow mesenchymal stem cells[J]. Gastrenterology , 2008, 134 (7) : 2111-2121.
    [18] Kim WH, Matsumoto K, Bessho K, et al. Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis[J]. Am J Pathol, 2005, 166 (7) : 1017-1028.
    [19]Carvalho AB, Quintanilha LF, Dias JV, et al.Bone marrowmultipotent mesenchymal stromal cells do not reduce fibrosisor improve function in arat model of severe chronic liver inju-ry[J].Stem Cells, 2008, 26:1307-1314.
    [20]Chen Z, Qi LZ, Zeng R, et al.Stem cells and hepatic cirrho-sis[J].Panminerva Med, 2010, 52 (2) :149-165.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (3766) PDF downloads(637) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return