Association of menopausal time and menopausal age with nonalcoholic fatty liver disease： An analysis based on a restricted cubic spline model

Chenlu ZHAO; Suping MA; Dongfang SHANG; Sutong LIU; Xiaoyan LIU; Yuanyuan ZHENG; Wenxia ZHAO

doi:10.12449/JCH250209

Volume 41 Issue 2

Feb. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(2): 247-253

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Association of menopausal time and menopausal age with nonalcoholic fatty liver disease： An analysis based on a restricted cubic spline model

DOI: 10.12449/JCH250209

1.
Department of Spleen，Stomach，Liver and Gallbladder Diseases，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
2.
The First Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450000，China

Research funding:

The Second National Famous Chinese Medicine Studio Construction Project (National Office of Traditional Chinese Medicine ［2022］ No.245);

Henan Province Traditional Chinese Medicine Double First-class Creation Scientific Research Project (HSRP-DECTCM-2023-3-13);

Construction Project of Traditional Chinese Medicine Discipline in Henan Province (STG-ZYXKY-2020024)

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Corresponding author: ZHAO Wenxia， zhao-wenxia@163.com （ORCID： 0000-0001-6666-9469）
Received Date: 2024-06-29
Accepted Date: 2024-08-19
Published Date: 2025-02-25

Abstract

Abstract

Objective To investigate the association of menopausal time and menopausal age with the risk of nonalcoholic fatty liver disease （NAFLD）， and to provide a basis for the early prevention and treatment of NAFLD in clinical practice. Methods Related data were collected from 373 postmenopausal women who attended the outpatient service of Department of Spleen， Stomach， Liver and Gallbladder Diseases， The First Affiliated Hospital of Henan University of Chinese Medicine， from January 2017 to December 2021， including general information， menopausal age， menopausal time， and presence or absence of NAFLD. The chi-square test was used for comparison of categorical data； the independent-samples t test was used for comparison of normally distributed continuous data between groups， and the Wilcoxon rank-sum test was used for comparison of non-normally distributed continuous data between groups. A Logistic regression analysis was used to calculate the association intensity and 95% confidence interval （95%CI） of menopausal time and menopausal age for the risk of NAFLD， and the restricted cubic spline （RCS） method was used to investigate the dose-response relationship between menopausal time/age and the risk of NAFLD. Results Compared with the women with normal menopause or late menopause， the women with early menopause had a higher prevalence rate of NAFLD and a higher degree of steatosis and fibrosis （all P<0.05）. After adjustment for the confounding factors such as age and age of menarche， the risk of NAFLD in women with a menopausal time of >3 years was 4.80 （95%CI： 1.93‍ ‍—‍‍ ‍11.95， P=0.001） times that in women with a menopausal time of ≤3 years， and the risk of NAFLD in women with early or late menopause was 8.14 times （95%CI： ‍1.77 ‍— ‍37.58， P=0.007） and 0.09 times （95%CI： 0.03 ‍— ‍0.32， P<0.001）， respectively， that in those with a normal menopausal age. There is a dose-response relationship between menopausal time/age and the risk of NAFLD. Menopausal time is positively correlated with the association intensity of NAFLD， while menopausal age is negatively correlated with the association intensity of NAFLD. Conclusion The longer the menopause time and the earlier the menopause age， the ligher the risk of NAFLD.
- Non-alcoholic Fatty Liver Disease,
- Menopause,
- Restricted Cubic Spline

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References

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Association of menopausal time and menopausal age with nonalcoholic fatty liver disease： An analysis based on a restricted cubic spline model

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