Role of alkaloid compounds in regulating chronic liver diseases

Yihui ZHENG; Jiahui WANG; Tiejian ZHAO; Xuelin DUAN; Lei WANG; Yang ZHENG; Shiquan YANG

doi:10.12449/JCH250227

Volume 41 Issue 2

Feb. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(2): 375-382

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Role of alkaloid compounds in regulating chronic liver diseases

DOI: 10.12449/JCH250227

1.
Department of Medicine，Faculty of Chinese Medicine Science，Guangxi University of Chinese Medicine，Nanning 530222，China
2.
School of Zhuang Medicine，Guangxi University of Chinese Medicine，Nanning 530222，China

Research funding:

National Natural Science Foundation of China (82204755);

Guangxi Key Laboratory of Zhuang and Yao Medicines (GXZYYKF2023-05);

Guangxi Natural Science Foundation of China (2023GXNSFBA026274);

Guangxi Natural Science Foundation of China (2024GXNSFAA010235)

More Information

Corresponding author: ZHENG Yang， 1793853705@qq.com （ORCID： 0000-0001-7646-511X）; YANG Shiquan， duoduo6181@126.com （ORCID： 0009-0001-2092-2323）
Received Date: 2024-06-09
Accepted Date: 2024-09-14
Published Date: 2025-02-25

Abstract

Abstract

Chronic liver diseases with common causes including viral infections， alcohol abuse， and autoimmune diseases. Alkaloids， as a class of plant-derived compounds， have shown significant potential in regulating chronic liver diseases. Recent studies have shown that alkaloids are able to exert a therapeutic effect on chronic liver diseases through multiple pathways. These compounds have a regulatory effect on key pathological processes such as liver fibrosis， inflammatory response， oxidative stress， and cell apoptosis， and they also regulate the metabolic homeostasis of hepatocytes by modulating multiple signaling pathways， thereby playing a role in regulating chronic liver diseases. This article reviews the role and mechanism of alkaloids in the treatment of chronic liver diseases， in order to provide new ideas and directions for the treatment of chronic liver diseases.
- Alkaloids,
- Liver Diseases,
- Signal Transduction

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References(62)

References

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Role of alkaloid compounds in regulating chronic liver diseases

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Role of alkaloid compounds in regulating chronic liver diseases

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