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Volume 41 Issue 7
Jul.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(7): 1261-1265

Emphasizing the diagnosis and treatment of acute severe autoimmune hepatitis

DOI: 10.12449/JCH250705
  • a.

    Department of Gastroenterology/Shanghai Institute of Digestive Disease, Renji Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200001，China

  • b.

    Institute of Aging & Tissue Regeneration, Renji Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200001，China

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  • Corresponding author: MA Xiong， maxiongmd@163.com （ORCID： 0000-0001-9616-4672）
  • Received Date: 2025-04-16
  • Accepted Date: 2025-05-29
  • Published Date: 2025-07-25
    Abstract
  • At present， the diagnostic criteria for acute severe autoimmune hepatitis （AS-AIH） include acute onset， consistency with the diagnostic criteria for autoimmune hepatitis （AIH）， presence of jaundice， and international normalized ratio ≥1.5 at the time of diagnosis， without evidence of hepatic encephalopathy or previous liver disease. As a special subtype of AIH， AS-AIH is characterized by acute onset and rapid disease progression， and thus early diagnosis is of vital importance. Glucocorticoid therapy should be given as early as possible after diagnosis to prevent the progression to acute liver failure and reduce the risk of liver transplantation. Management of AS-AIH patients is challenging， since patients often lack typical clinical features and histological manifestations of AIH at the time of diagnosis， and early assessment of glucocorticoid response and a treatment regimen with proper doses are important for improving the prognosis of patients.

     

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