Primary biliary cholangitis and the gut microbiome

Zhibin ZHAO; Zhexiong LIAN

doi:10.12449/JCH250706

Volume 41 Issue 7

Jul. 2025

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Primary biliary cholangitis and the gut microbiome

DOI: 10.12449/JCH250706

Zhibin ZHAO,
Zhexiong LIAN^{,
,}

Guangdong Provincial People’s Hospital，Southern Medical University，Guangzhou 510080，China

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Corresponding author: LIAN Zhexiong， zxlian@gdph.org.cn （ORCID： 0000-0002-9525-1421）
Received Date: 2025-04-21
Accepted Date: 2025-05-20
Published Date: 2025-07-25

Abstract

Abstract

In recent years， an increasing amount of evidence has shown that intestinal flora disturbance plays a critical role in the pathogenesis of primary biliary cholangitis （PBC）. Intestinal flora participates in the development and progression of PBC by modulating bile acid metabolism， affecting immune system functions， and mediating interactions within the gut-liver axis. This article summarizes the pathophysiological features of PBC， elaborates on the mechanism of action of intestinal flora in PBC， and analyzes the potential treatment strategies based on intestinal flora regulation， in order to provide new theoretical bases for the early diagnosis and precise treatment of PBC.
- Primary Biliary Cholangitis,
- Gastrointestinal Microbiome,
- Bile Acids and Salts,
- Immune System

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References(41)

References

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Primary biliary cholangitis and the gut microbiome

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