On May 10, 2025, the European Association for the Study of the Liver (EASL) released the latest version of Clinical Practice Guidelines on the Management of Chronic Hepatitis B Virus Infection. Based on the latest research advances, the guidelines provide comprehensive recommendations for the diagnosis, treatment, and prevention of HBV infection, covering ten key areas of diagnostic criteria, treatment goals, indications for treatment, therapeutic strategies, hepatocellular carcinoma surveillance, management of special populations, prevention of HBV reactivation, post-transplant care, prevention strategies, and future research priorities. This article summarizes and makes an excerpt of the key recommendations from the updated guidelines.