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CN 22-1108/R
Volume 41 Issue 7
Jul.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(7): 1358-1363

Association between liver radiodensity and the degree of liver fibrosis in patients with chronic hepatitis B

DOI: 10.12449/JCH250720
  • 1.

    The First Clinical Medical College of Lanzhou University，Lanzhou 730000，China

  • 2.

    Department of Radiology，The First Hospital of Lanzhou University，Lanzhou 730000，China

  • 3.

    Department of Hepatology，The First Hospital of Lanzhou University，Lanzhou 730000，China

  • 4.

    Institute of Portal Hypertension，The First Hospital of Lanzhou University，Lanzhou 730000，China

  • 5.

    Department of Infectious Diseases，The First Hospital of Lanzhou University，Lanzhou 730000，China

Research funding:

National Natural Science Foundation of China (82360132);

Gansu Province Joint Scientific Research Fund Project (23JRRA1489);

Gansu Province Joint Scientific Research Fund Project (24JRRA911);

Lanzhou Science and Technology Programme (2023-2-76);

Major Scientific Research Project on Science and Technology Innovation in Gansu Health Sector (GSWSZD2024-11);

Beijing Hepatology Foundation (iGandanF-1082023-RGG002);

Beijing Hepatology Foundation (iGandanF-1082024-RGG130)

More Information
  • Corresponding author: ZHANG Liting， zlt08@qq.com （ORCID： 0009-0005-1259-5747）; LI Junfeng， junfenglee@126.com （ORCID： 0000-0002-5638-706X）
  • Received Date: 2024-11-06
  • Accepted Date: 2024-11-27
  • Published Date: 2025-07-25
    Abstract
  •   Objective  To investigate the association of liver radiodensity with the degree and progression of liver fibrosis in patients with chronic hepatitis B （CHB）.  Methods  A retrospective cohort study was conducted among 114 CHB patients who were hospitalized in The First Hospital of Lanzhou University from January to December 2019， and related clinical data were collected， including laboratory tests and abdominal CT. The metabolic characteristics of the patients were assessed， and liver radiodensity was measured. An analysis of variance was used for comparison of normally distributed continuous data between three groups， and the Kruskal-Wallis H rank sum test was used for comparison of continuous data with skewed distribution between three groups； the chi-square test or the Fisher’s exact test was used for comparison of categorical data between three groups. A logistic regression analysis was used to investigate the influencing factors for the degree of liver fibrosis， and the Cox proportional-hazards regression model analysis was used to investigate the influencing factors for the progression of liver fibrosis in CHB.  Results  Among the 114 patients enrolled， 43 （37.72%） had no liver cirrhosis， 30 （26.32%） were suspected of liver cirrhosis， and 41 （35.96%） had liver cirrhosis， with a median follow-up time of 538.5 （322.75 — 1 031.50） days. Liver radiodensity on plain scan （odds ratio ［OR］=0.81， 95% confidence interval ［CI］： 0.68 — 0.97， P=0.025）， liver radiodensity on contrast-enhanced scan （OR=0.95， 95%CI： 0.90 — 0.99， P=0.037）， and liver volume （OR=0.99， 95%CI： 0.98 — 0.99， P<0.001） were independent influencing factors for the degree of liver fibrosis. The univariate Cox regression analysis showed that the low level of HDL （hazard ratio=2.81， 95%CI： 1.04 — 7.54， P=0.041） was associated with the progression of liver fibrosis in CHB patients， and the degree of liver fibrosis， liver volume， and liver radiodensity showed no significant association with the progression of liver fibrosis （all P>0.05）.  Conclusion  In CHB patients， liver radiodensity is an independent influencing factor for the degree of liver fibrosis， and low HDL has a marked influence on the progression of liver fibrosis.

     

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