The role of insulin clearance in metabolic associated fatty liver disease

Xiaojing ZHU; Jun SHI; Hailin TANG; Liang ZHOU

doi:10.12449/JCH250728

Volume 41 Issue 7

Jul. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(7): 1414-1418

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The role of insulin clearance in metabolic associated fatty liver disease

DOI: 10.12449/JCH250728

Xiaojing ZHU¹,
Jun SHI²,
Hailin TANG²,
Liang ZHOU^{3, 4
,
,
,}

1.
Department of Pharmacy
2.
Department of Hepatology，Suzhou Hospital of Integrated Traditional Chinese and Western Medicine，Suzhou，Jiangsu 215101，China
3.
Central Laboratory，Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine，Suzhou，Jiangsu 215009，China
4.
Central Laboratory，Suzhou Wumen Medical School Research Institute，Suzhou，Jiangsu 215009，China

Research funding:

Scientific Research Project of Jiangsu Commission of Health (Z2020030);

Basic Research Plan Project of Suzhou 2023（Medical Application Basic Research） (SKYD2023075);

Research Project of Gusu Health Talent and Program Talent (GSWS2023062);

Science and Technology Programs Project of Wuzhong District 2023 (wzyw2023010);

Science and Technology Development Plan of Suzhou 2023（Basic Research-Medical Application Basic Research） Guiding Project (SKYD2023244)

More Information

Corresponding author: ZHOU Liang， zhouliangsz@yeah.net （ORCID： 0000-0003-0188-2044）
Received Date: 2024-11-09
Accepted Date: 2025-01-02
Published Date: 2025-07-25

Abstract

Abstract

With the rapid changes in lifestyle， the prevalence of nonalcoholic fatty liver disease （NAFLD） has become increasingly severe in China， and it has become a major public health concern. With a deeper understanding of this disease， the latest consensus statement has changed the name from NAFLD to MAFLD， and this updated definition transitions from an exclusion-based approach to an inclusive framework， which not only improves clinical diagnostic accuracy， but also highlights the key role of metabolic disorders in the progression of NAFLD. In recent years， the in-depth studies on the mechanism of carcinoembryonic antigen-associated cell adhesion molecule 1-mediated insulin clearance have highlighted the importance of insulin clearance in the development and progression of NAFLD. This article reviews the research advances in the role of insulin clearance in MAFLD.

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References(42)

References

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The role of insulin clearance in metabolic associated fatty liver disease

DOI: 10.12449/JCH250728

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The role of insulin clearance in metabolic associated fatty liver disease

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