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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 41 Issue 7
Jul.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(7): 1450-1455

Effect of Siwu Decoction in the prevention and treatment of liver diseases and its mechanism

DOI: 10.12449/JCH250734
  • 1.

    Spleen，Stomach and Hepatobiliary Department，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

  • 2.

    The First Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450046，China

Research funding:

National Natural Science Foundation of China (81904154);

National Natural Science Foundation of China (82205086);

Henan Province’s Science and Technology Assault Plan (242102310500);

Henan Province’s Science and Technology Assault Plan (232102310438);

Special Project on Inheritance and Innovation in Traditional Chinese Medicine by the Henan Health Commission (2023ZXZX1162);

Henan Health Commission (2022JDZX114);

Scientific Research Special Project under the “Double First-Class” Initiative for Traditional Chinese Medicine in Henan Province (HSRP-DFCTCM-2023-1-10);

Joint Fund for R&D in Science and Technology, Focusing on Advantage Discipline Cultivation Type, in Henan Province (242301420096)

More Information
  • Corresponding author: LIU Minghao， liumh015@163.com （ORCID： 0009-0001-7712-4605）
  • Received Date: 2024-11-01
  • Accepted Date: 2025-02-25
  • Published Date: 2025-07-25
    Abstract
  • Siwu Decoction is a classic formula for tonifying the blood and activating blood circulation and is characterized by its ability to tonify the blood without leaving stasis and promote blood circulation without harming the vital energy of the body. It is widely used in clinical practice for the treatment of various conditions related to blood deficiency and poor blood circulation， such as anemia， menstrual disorders， and dysmenorrhea. The liver is responsible for governing the free flow of Qi and storing blood， and abnormalities in liver function are associated with various acute and chronic liver injuries. Siwu Decoction can restore liver homeostasis by tonifying the blood， activating blood circulation， nourishing the blood， and soothing the liver. Based on its unique prescription formulation and multiple pharmacological mechanisms， Siwu Decoction has become an important prescription for enhancing liver microcirculation， facilitating hepatocyte repair and regeneration， and alleviating liver injury. This article reviews the effect and mechanism of Siwu Decoction in the prevention and treatment of various liver injuries （including alcoholic liver disease， nonalcoholic fatty liver disease， nonalcoholic fatty liver disease， liver fibrosis， and liver cirrhosis） and discusses existing problems and future research directions.

     

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