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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 41 Issue 10
Oct.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(10): 2062-2067

Influencing factors for quality of life in patients with primary biliary cholangitis： A systematic review

DOI: 10.12449/JCH251016

  • Department of Gastroenterology，The First Affiliated Hospital of Air Force Medical University，Xi’an 710032，China

Research funding:

National Natural Science Foundation of China (82270551)

More Information
  • Corresponding author: HAN Ying， hanying@fmmu.edu.cn （ORCID： 0000-0003-3046-9507）
  • Received Date: 2025-03-24
  • Accepted Date: 2025-06-09
  • Published Date: 2025-10-25
    Abstract
  •   Objective  To investigate the core influencing factors for quality of life in patients with primary biliary cholangitis through a systematic review， and to provide an evidence-based basis for understanding such factors.  Methods  The databases including CNKI， Wanfang Data， CBM， VIP， PubMed， Embase， Web of Science， Ovid， Scopus， and Medline were searched for articles assessing the influencing factors for quality of life in patients with primary biliary cholangitis using PBC-40 scale published up to January 11， 2025. Quality assessment was conducted using the scale compiled by the Agency for Healthcare Research and Quality， and then a qualitative evaluation was performed for the basic situation of the studies included in the analysis.  Results  A total of 11 articles were included， and the results showed that age， sex， albumin， alkaline phosphatase， gamma-glutamyl transferase， direct bilirubin， total bilirubin， total bile acid， alanine aminotransferase， aspartate aminotransferase， body mass index， and high-density lipoprotein cholesterol were important influencing factors for quality of life in patients with primary biliary cholangitis.  Conclusion  Influencing factors include demographic features， liver function parameters， and physical and metabolic indicators； however， due to the limited number of studies， more high-quality large-sample studies are needed in the future.

     

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