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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 12
Dec.  2013
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Article Contents

Relationship between nonalcoholic fatty liver disease and adipocyte fatty acid- binding protein

DOI: 10.3969/j.issn.1001-5256.2013.12.010
  • Received Date: 2013-09-16
  • Published Date: 2013-12-20
  • Objective To investigate the relationship between nonalcoholic fatty liver disease ( NAFLD) and serum level of adipocyte fatty acid-binding protein ( AFABP) . Methods A total of 160 patients who underwent physical examination in the Affiliated Hospital of Ningxia Medical University from July to November 2010 were included in our study. These subjects were divided into two groups according to the diagnostic criteria for NAFLD formulated by the Chinese Medical Association: control group ( n = 71) and NAFLD group ( n = 89) . The two groups were compared with respect to general condition, body mass index ( BMI) , blood pressure, AFABP, serum insulin, and other serological indices. The relationship of serum AFABP with NAFLD and other metabolic parameters was analyzed using the Spearman linear correlation coefficient. Comparison of measurement data was made by t test and rank sum test; comparison of enumeration data was made by chi-square test. Results There were more males than females in the NAFLD group. Compared with the control group, the NAFLD group had higher BMI and levels of blood glucose, triglyceride ( TG) , aspartate aminotransferase ( AST) , alanine aminotransferase ( ALT) , and uric acid and lower high-density lipoprotein ( HDL) level; in addition, the NAFLD group had significantly higher serum AFABP and insulin levels and homeostasis model assessment-estimated insulin resistance ( HOMA-IR) . The Spearman correlation analysis showed that serum AFABP was positively correlated with NAFLD, BMI, HOMA-IR, serum insulin, blood glucose, TG, ALT, AST, and uric acid but negatively correlated with HDL. After adjustment for sex, age, and BMI, serum AFABP was positively correlated with NAFLD, HOMA-IR, serum insulin, blood glucose, TG, ALT, and uric acid, but had no significant correlation with HDL and AST. Conclusion Serum AFABP is closely associated with NAFLD and may be an independent plasma marker of this disease. AFABP plays a causative role in the pathogenesis of NAFLD.

     

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