ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 12
Dec.  2013
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Research advances in gene polymorphisms in nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2013.12.020
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  • Received Date: 2013-05-13
  • Published Date: 2013-12-20
  • The incidence of non-alcoholic fatty liver disease ( NAFLD) is rising worldwide. Investigation of genes involved in the pathogenesis of NAFLD is significant for improving treatment regimen and prognosis. Differences in prevalence of NAFLD between races suggest genetic contribution in this disease. PNPLA3 and apoC-III genes, which have become research hotspots in recent years, play important roles in the regulation of lipid metabolism. Studies have established an association of PNPLA3 gene variant ( rs738409[G], encoding I148M) and two single nucleotide polymorphisms (-455T > C [rs2854116]and-482C > T [rs285417]) in the insulin response element in the apoC-III promoter region with NAFLD. The previous research achievements are summarized to conclude that PNPLA3 can be used as an independent predictor of the incidence of NAFLD. However, no consensus has been reached regarding apoC-III among the studies worldwide, and the relevant research in China is still in the primary stage. New ideas are explored for future research on the pathogenesis of NAFLD.


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