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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 7
Jul.  2014
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Article Contents

Value of FibroScan in diagnosis of hepatic fibrosis in patients with HBeAg-negative chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2014.07.011
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  • Received Date: 2013-12-09
  • Published Date: 2014-07-20
  • Objective To evaluate the value of transient elastography (FibroScan, FS) in predicting hepatic fibrosis in patients with HBeAg- negative chronic hepatitis B (CHB) . Methods One hundred and four patients with HBeAg- negative CHB, who were diagnosed and treated in Hubei Hospital of Traditional Chinese Medicine from June 2011 to May 2013, were enrolled in this study. All patients underwent FS for liver stiffness measurement before liver biopsy. Statistical analysis was applied to compare liver stiffness (kPa) with fibrosis stage (determined by liver biopsy) . The receiver operating characteristic ( ROC) curve of FS was constructed, and the area under the ROC curve (AUC) was calculated to analyze the accuracy of live stiffness in predicting significant fibrosis and cirrhosis. Comparison between groups was made by Kruskal- Wallis H test, followed by Mann- Whitney U test for multiple comparisons. The correlation between two variables was analyzed by Spearman rank and Pearson correlation test. Results Liver stiffness gradually rose as the degree of hepatic fibrosis increased, with significant differences between groups (P < 0. 01 or P < 0. 05) . Liver stiffness was positively correlated with the stage of hepatic fibrosis (r =0.810, P <0.01) . The AUC of liver stiffness for detecting liver cirrhosis was 0.956; the cut-off value for diagnosing liver cirrhosis was13. 1 kPa; the sensitivity was 92. 7%, and the specificity was 80%. Conclusion FS is a promising noninvasive method for the assessment of hepatic fibrosis in patients with HBeAg- negative CHB; particularly, it has high accuracy in the diagnosis of liver cirrhosis. FS combined with direct or indirect markers may play an important role in differential diagnosis and efficacy evaluation in patients with hepatic fibrosis.

     

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  • [1]XIAO Q, LIU ZQ, FENG JH, et al.Clinical value of Fibroscan for detecting liver fibrosis in patients with chronic hepatitis B and effects of ALT and AST on diagnosis[J].J Clin Hepatol, 2012, 28 (9) :654-656. (in Chinese) 孝奇, 刘志权, 冯军花, 等.Fibroscan对慢性乙型肝炎肝纤维化患者的应用价值及ALT、AST对其诊断的影响[J].临床肝胆病杂志, 2012, 28 (9) :654-656.
    [2]LIU KH, WU HQ, RUAN J, et al.The value of Fibroscan in diagnosis of hepatic fibrosis in CHB patients and influencing factors[J].Chin Hepatol, 2012, 17 (9) :621-625. (in Chinese) 刘柯慧, 吴海清, 阮隽, 等.Fibroscan在慢性乙型肝炎肝纤维化诊断中的作用及影响因素[J].肝脏, 2012, 17 (9) :621-625.
    [3] Chinese Society of Hepatology, Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline for prevention and treatment of chronic hepatitis B (2010) [J].J Clin Hepatol, 2011, 27 (1) :Ⅰ-ⅩⅥ. (in Chinese) 中华医学会肝病学分会, 感染病学分会.慢性乙型肝炎防治指南 (2010年版) [J].临床肝胆病杂志, 2011, 27 (1) :Ⅰ-ⅩⅥ.
    [4]CHEN YX, SHI YL.Research advances in HBeAg-negative chronic hepatitis B[J].J Medical Forum, 2010, 31 (15) :205-207. (in Chinese) 陈育霞, 施雅利.e抗原阴性的慢性乙型肝炎研究进展[J].医药论坛杂志, 2010, 31 (15) :205-207.
    [5]de LDINGHEN V, VERGNIOL J.Transient elastography for the diagnosis of liver fibrosis[J].Expert Rev Med Devices, 2010, 7 (6) :811-823.
    [6]TAKEDA T, YASUDA T, NAKAYAMA Y, et al.Usefulness of noninvasive transient elastography for assessment of liver fibrosis stage in chronic hepatitis C[J].World J Gastroenterol, 2006, 12 (48) :7768-7773.
    [7]WEI XF, XU P, LI H, et al.Diagnostic value of combined determination of serum hepatic fibrosis indices and liver function indices for hepatic fibrosis in patients with chronic hepatitis B[J].Int J Lab Med, 2012, 33 (18) :2278-2280. (in Chinese) 魏雪菲, 徐佩, 李菡, 等.血清肝纤维化指标和肝功能指标联合检测在慢性乙型肝炎肝纤维化诊断中的价值[J].国际检验医学杂志, 2012, 33 (18) :2278-2280.
    [8]LINDEN RA, HAIPEM EJ.Advances in transrectal ultrasound imaging of the prostate[J].Semin Ultrasound CT MR, 2007, 28 (4) :249-257.
    [9]DU D, ZHU X, KUNO A, et al.Comparison of LecT-Hepa and Fibroscan for assessment of liver fibrosis in hepatitis B virus infected patients with different ALT levels[J].Clin Chim Acta, 2012, 413 (21-22) :1796-1799.
    [10]WANG YJ, TANG SS.Assessment of hepatic fibrosis stage by transient elastography:An meta-analysis[J].Chin J Med Imaging Technol, 2012, 28 (3) :529-533. (in Chinese) 王一娇, 唐少珊.瞬时弹性成像评价肝纤维化分级的Meta分析[J].中国医学影像技术, 2012, 28 (3) :529-533.
    [11]POYNARD T, NGO Y, MUNTEANU M, et al.Noninvasive markers of hepatic fibrosis in chronic hepatitis B[J].Curr Hepat Rep, 2011, 10 (2) :87-97.
    [12]GOYAL R, MALLICK SR, MAHANTA M, et al.Fibroscan can avoid liver biopsy in Indian patients with chronic hepatitis B[J].J Gastroenterol Hepatol, 2013, 28 (11) :1738-1745.
    [13]XIAO Q, FENG AD, LIU ZQ, et al.Value and impact factors of transient elastography in diagnosis of hepatic B cirrhosis[J].Clin Focus, 2013, 28 (8) :855-860. (in Chinese) 孝奇, 冯爱东, 刘志权, 等.瞬时弹性成像在诊断乙型肝炎后肝硬化中的价值及影响因素[J].临床荟萃, 2013, 28 (8) :855-860.
    [14]XUE F, SHI YX, LI GM, et al.Diagnostic value of Fibroscan in hepatic Fibrosis[J].Chin J Clin Med, 2012, 19 (1) :77-79. (in Chinese) 薛芳, 施裕新, 李桂明, 等.瞬时弹性成像对肝纤维化的诊断价值[J].中国临床医学, 2012, 19 (1) :77-79.
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