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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 7
Jul.  2014
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Clinical features and related factors for Kawasaki disease with liver damage

DOI: 10.3969/j.issn.1001-5256.2014.07.023
  • Received Date: 2013-02-08
  • Published Date: 2014-07-20
  • Objective To study the features of Kawasaki disease (KD) with liver damage and investigate the possible related factors, and to improve the understanding of liver damage in KD patients. Methods The clinical data of 75 KD patients admitted from 2008 to 2013 were collected to retrospectively analyze the clinical features of liver damage, as well as routine blood test, C- reactive protein (CRP) , erythrocyte sedimentation rate (ESR) , liver function, and abdominal ultrasound. Categorical data were analyzed by chi- square test; continuous data were expressed as mean ± standard deviation; comparison between groups was made by t test and multivariate stepwise regression analysis. Results The incidence of abnormal alanine aminotransferase (ALT) level in 75 cases was 32%, and 79. 2% of these patients had a serum ALT level of less than 200 IU /L, including 3 patients with hepatomegaly, 1 patient with jaundice, and 1 patient with splenomegaly, which accounted for 12. 5%, 4. 2%, and 4. 2%, respectively, of patients with liver damage. CRP and ESR were not found to be related to liver damage (t = 1. 560, P = 0. 123; t = 1. 291, P = 0. 201) . There was significant difference in platelet count between patients with liver damage and controls (t =- 3. 228, P = 0. 003) . No significant difference in white blood cell (WBC) count increase was found between the liver damage group and control group, but simultaneous increase in WBC count and platelet count was significantly associated with an increased risk of liver damage (P < 0. 05) . Conclusion CRP and ESR are not found to be significantly related to the development of liver damage, but there is a close relationship between liver damage and abnormal platelet count. WBC count shows a certain relationship with liver damage. Clinicians should pay attention to these factors and take timely measures for intervention.

     

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  • [1]AYUSAWA M, SONOBE T, UEMURA S, et al.Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition) [J].Pediatr Int, 2005, 47 (2) :232-234.
    [2]GE T, DU PF.Retrospective analysis of 120 cases with Kawasaki disease complicated organ damage[J]Chin J Cardiovascular Rehabil Med, 2012, 21 (1) :76-78. (in Chinese) 葛婷, 都鹏飞.120例川崎病合并脏器损害回顾性分析[J].心血管康复医学杂志, 2012, 21 (1) :76-78.
    [3]ZHANG XL.Analysis of liver function in patients with Kawasaki disease[J].Acta Med Sinica, 2011, 24 (1) :57-58. (in Chinese) 张雪琳.川崎病患者的肝功能分析[J].华夏医学, 2011, 24 (1) :57-58.
    [4]LI XM, CHEN MZ, XU FM, et al.Clinical significance of CD62p, CD63 and vascular endothelial function in the children with Kawasaki Disease[J].Pract J Med Pharm, 2005, 22 (2) :956-958. (inChinese) 李香梅, 陈铭珍, 许逢明, 等.川崎病患儿CD62p、CD63与血管内皮功能变化的临床意义[J].实用医药杂志, 2005, 22 (2) :956-958. (in Chinese)
    [5]HOU SS, ZHANG XR, ZHAO YH.Role and action mechanism of8-iso-PGF2αin traumatic liver diseases[J].J Clin Hepatol, 2013, 29 (2) :956-958. (in Chinese) 侯珊珊, 张小瑞, 赵远红.8-异前列腺素F2α在损伤性肝脏疾病中的作用与机制[J].临床肝胆病杂志, 2013, 29 (12) :956-958.
    [6]TAKAFIRAII T, TADASHI K, SUGIRU P, et al.Interaction between Kupffer cells and platelets in the early period of hepatic ischemia-reperfusion injxny-an invivo study[J].J Surg Res, 2012, 178 (1) :443-451.
    [7]KOENEN RR, von HUNDELSHAUSEN P, NESMELOVA IV, et al.Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice[J].Nat Med, 2009, 15 (1) :97-103.
    [8]SELZNER N, RUDIGER H, GRAF R, et al.Protective strategies against ischemic injury of the liver[J].Gastroenterology, 2003, 125 (3) :917-936.
    [9]ANAYA-PRADO R, TOLEDO-PEREYRA LH, LENTSCH AB, et al.Ischemia/reperfusion injury[J].J Surg Res, 2002, 105 (2) :248-258.
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