中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 32 Issue 1
Jan.  2016
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Article Contents

Correlation between platelet indices and liver pathological staging: an analysis of 167 patients with chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2016.01.019
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  • Received Date: 2015-05-05
  • Published Date: 2016-01-20
  • Objective To investigate the values of aspartate aminotransferase to platelet ratio index( APRI) and alanine aminotransferase to platelet ratio index( BPRI) for the prediction of pathological changes in liver tissue in patients with chronic hepatitis B( CHB). Methods A total of 167 CHB patients who visited the People's Hospital of Liuzhou from February 2004 to February 2014 were collected. Liver biopsy,routine blood test,and liver function test were performed,and then the correlation between APRI / BPRI and liver pathology was analyzed.The Mann- Whitney U test was applied for comparison of continuous data between groups,and the receiver operating characteristic( ROC)curve was used to evaluate the predictive values of APRI and BPRI for liver pathological staging. Results APRI was compared between G0,G1,G2,G3,and G4 groups with different liver inflammation grades,and the G1 group had a significantly different APRI value than the G2 and G3 groups( both P < 0. 05); the G0- 1 group had a significantly different APRI value than the G2- 4 group( P < 0. 05). BPRI was also compared between these groups,and it differed significantly between the G0 group and G4 group and between the G1 group and G2 group( both P < 0. 05); the G0- 1 group had a significantly different BPRI value than the G2- 4 group( P < 0. 05). APRI and BPRI were compared between each two of S0,S1,S2,S3,and S4 groups,and they showed significant differences between the S2 and S3 groups( P <0. 05). The areas under the ROC curve of APRI and BPRI for predicting liver inflammation G2- 4 were 0. 748 and 0. 736,respectively( 95% CI: 0. 669- 0. 827 and 0. 653- 0. 819,respectively; both P < 0. 000 1); the optimal cut- off values for APRI and BPRI to predict liver inflammation G2- 4 were 0. 601 and 0. 630,respectively,with sensitivity,specificity,and Youden index of 63. 6% /82. 7%,74. 5% /59. 6%,and 39. 0% /42. 4%,respectively. Conclusion APRI and BPRI can be used to predict liver inflammatory activity in CHB patients.

     

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  • [1]CHANG MH.Hepatitis B virus infection[J].Semin Fetal Neonatal Med,2007,12(3):160-167.
    [2]ZHANG ZH,YANG SW.Dynamic changes of serum markers in patients with chronic hepatitis B[J].Int J Virol,2015,22(4):270-273.(in Chinese)张正怀,杨树伟.慢性乙型肝炎患者两对半指标变化监测分析[J].国际病毒学杂志,2015,22(4):270-273.
    [3]SUN DC,CHEN L,WU ZY,et al.Diagnosis and management of the hepatitis B reactivation in patients receiving cytotoxic chemotherapy[J].Chin J Clin Pharmacol Ther,2014,19(5):584-590.(in Chinese)孙德聪,陈丽,吴志勇,等.化疗相关乙肝病毒再激活的诊治现状[J].中国临床药理学与治疗学,2014,19(5):584-590.
    [4] Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association.The guideline of prevention and treatment for chronic hepatitis B(2010 version)[J].J Clin Hepatol,2011,27(1):Ⅰ-ⅩⅥ.(in Chinese)中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2010年版)[J].临床肝胆病杂志,2011,27(1):Ⅰ-ⅩⅥ.
    [5]WAI CT,GREENSON JK,FONTANA RJ,et al.A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C[J].Hepatology,2003,38(2):518-526.
    [6]Chinese Society of Infectious Diseases and Parasitology,Chinese Society of Hepatology,Chinese Medical Association.Prevention and treatment of viral hepatitis[J].Chin J Hepatol,2000,8(6):324-329.(in Chinese)中华医学会传染病与寄生虫病学分会、肝病学分会.病毒性肝炎防治方案[J].中华肝脏病杂志,2000,8(6):324-329.
    [7]MA JJ,FENG LY,FENG ZJ,et al.Relationship of liver pathology and clinical data of HBV-infected patients with normal or mildly abnormal alanine aminotransferase level[J].Chin Gen Pract,2013,16(5B):1603-1606.(in Chinese)马俊骥,冯丽英,冯志杰,等.丙氨酸氨基转移酶正常或轻度异常乙型肝炎病毒感染者肝病理与临床关系研究[J].中国全科医学,2013,16(5B):1603-1606.
    [8]BOURLIERE M,PENARANDA G,OUZAN D,et al.Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients[J].Aliment Pharmacol Ther,2008,28(4):458-467.
    [9]SHAHEEN AA,MYERS RP.Diagnostic accuracy of the aspartate aminotransferase-to-platelet ratio index for the prediction of hepatitis C-related fibrosis:a systematic review[J].Hepatology,2007,46(3):912-921.
    [10]SEBASTIANI G,CASTERA L,HALFON P,et al.The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers:an international study of 2411 cases[J].Aliment Pharmacol Ther,2011,34(10):1202-1216.
    [11]PAN JJ,SUN QL.Clinical utility of aspartate aminotransferase to platelet ratio index in chronic hepatitis B virus infection with transaminase less than two times of upper limits of normal[J].Chin J Infect Dis,2014,32(1):48-51.(in Chinese)潘劲劲,孙秋林.天冬氨酸转氨酶与血小板比值在转氨酶正常值上限两倍以下慢性乙型肝炎病毒感染者中的临床应用评价[J].中华传染病杂志,2014,32(1):48-51.
    [12]FENG F,MA SM,CHEN F,et al.Diagnostic value of LSM combined with APRI for liver fibrosis due to chronic hepatitis B[J].J Clin Hepatol,2013,29(10):752-755.(in Chinese)冯菲,马苏美,陈飞,等.肝硬变检测联合APRI指数对慢性乙型肝炎患者肝纤维化程度的诊断价值[J].临床肝胆病杂志,2013,29(10):752-755.
    [13]ZHU X,WANG LC,CHEN EQ,et al.Prospective evaluation of Fibro Scan for the diagnosis of hepatic fibrosis compared with liver biopsy/AST platelet ratio index and FIB-4 in patients with chronic HBV infection[J].Dig Dis Sci,2011,56(9):2742-2749.
    [14]CHOU YC,YU MW,WU CF,et al.Temporal relationship between hepatitis B virus enhancerⅡ/basal core promoter sequence variation and risk of hepatocellular carcinoma[J].Gut,2008,57(1):91-97.
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