ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2016
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Article Contents

Mechanism of action of direct-acting antiviral agents in treatment of chronic hepatitis C

DOI: 10.3969/j.issn.1001-5256.2016.09.013
  • Published Date: 2016-09-20
  • With the development and launch of direct- acting antiviral agents( DAAs) in the world in recent years,therapeutic regimens for chronic hepatitis C are constantly evolving. DAAs will also be launched in China in the near future. DAAs mainly target at the non-structural proteins of HCV and can inhibit HCV RNA replication. This article introduces the targets,mechanism of action,and resistance characteristics of different DAAs,as well as their current research and development in China and the results of phase Ⅲ clinical studies,in order to provide a reference for combined therapeutic strategies with DAAs in the treatment for chronic hepatitis C.


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