中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2016
Turn off MathJax
Article Contents

The role of MAPK signaling pathway in development/progression and treatment of liver cancer

DOI: 10.3969/j.issn.1001-5256.2016.09.040
Research funding:

 

  • Published Date: 2016-09-20
  • Abnormal activation of the mitogen- activated protein kinase( MAPK) signaling pathway is closely associated with the development,progression,and metastasis of liver cancer. This article introduces the expression of MAPK proteins in liver cancer and its role in the proliferation,differentiation,and metastasis of liver cancer,and elaborates on the value of the MAPK signaling pathway in the treatment and prognostic evaluation of liver cancer. It is pointed out that the MAPK signaling pathway plays an important role in the development/progression and treatment of liver cancer and is a potential molecular target for the treatment and prognostic evaluation of liver cancer.

     

  • loading
  • [1]MUNSHI A,RAMESH R.Mitogen-activated protein kinases and their role in radiation response[J].Genes Cancer,2013,4(9-10):401-408.
    [2]LI JF,DENG YD,ZHANG LT,et al.The role of Ras/ERK signal transduction pathway in the occurrence and development of hepatic fibrosis[J].J Clin Hepatol,2011,27(3):325-327.(in Chinese)李俊峰,邓永东,张立婷,等.Ras/ERK信号转导通路在肝纤维化发生发展中的作用[J].临床肝胆病杂志,2011,27(3):325-327.
    [3]DELIRE B,STARKEL P.The Ras/MAPK pathway and hepatocarcinoma:pathogenesis and therapeutic implications[J].Eur J Clin Invest,2015,45(6):609-623.
    [4]HAN T,XIANG D M,SUN W,et al.PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients[J].J hepatol,2015,63(3):651-660.
    [5]BERASAIN C,NICOU A,GARCIA-IRIGOYEN O,et al.Epidermal growth factor receptor signaling in hepatocellular carcinoma:inflammatory activation and new intracellular regulatory mechanism[J].Dig Dis,2012,30(5):524-531.
    [6]YANG L,ZHAO LY,LIU YC,et al.CB1 and ERK gene expression in liver tissue of rats with experimental hepatic fibrosis[J].J Clin Hepatol,2012,28(9):681-684.(in Chinese)杨莉,赵连英,刘彦超,等.大麻素受体1和细胞外信号调节激酶在肝纤维化小鼠肝组织中的表达及意义[J].临床肝胆病杂志,2012,28(9):681-684.
    [7]WANG HY,YANG SL,LIANG HF,et al.HBx protein promotes oval cell proliferation by up-regulation of cyclin D1 via activation of the MEK/ERK and PI3K/Aktpathways[J].Int J Mol Sci,2014,15(3):3507-3518.
    [8]YE H,ZHANG C,WANG BJ,et al.Synergistic function of Kras mutation and HBx in initiation and progression of hepatocellular carcinoma in mice[J].Oncogene,2014,33(43):5133-5138.
    [9]NAKAMURA H,AOKI H,HINO O,et al.HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt[J].Hepatol Res,2011,41(5):455-462.
    [10]XIE B,XING R,CHEN P,et al.Down-regulation of c-Met expression inhibits human HCC cells growth and invasion by RNA interference[J].J Surg Res,2010,162(2):231-238.
    [11]ZHOU P,HUANG G,ZHAO Y,et al.MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells[J].Cell Signal,2014,26(6):1347-1354.
    [12]KOUL KH,PAL M,KOUL S,et al.Role of p38 MAP kinase signal transduction in solid tumors[J].Genes Cancer,2013,4(9-10):342-359.
    [13]ESCOS A,RISCO A,ALSINA-BEAUCHAMP D,et al.p38gamma and p38delta mitogen activated protein kinases(MAPKs),new stars in the MAPK galaxy[J].Front Cell Dev Biol,2016,4:31-38.
    [14]CHEN KC,CHANG LS.Notexin upregulates Fas and Fas L protein expression of human neuroblastoma SK-N-SH cells through p38MAPK/ATF-2 and JNK/c-Jun pathways[J].Toxicon,2010,55(4):754-761.
    [15]AMAKO Y,IGLOI Z,MANKOURI J,et al.Hepatitis C virus NS5A inhibits mixed lineage kinase3 to block apoptosis[J].J Biol Chem,2013,288(34):24753-24763.
    [16]SONG MK,PARK YK,RYU JC.Polycyclic aromatic hydrocarbon(PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cellmigration by targeting MAPK phosphatase-5,regulating the activation of p38 MAPK[J].Toxicol Appl Pharmacol,2013,273(1):130-139.
    [17]YIN J,WANG L,ZHU JM,et al.Prp19 facilitates invasion of hepatocellular carcinoma via p38 mitogen-activated protein kinase/twist1 pathway[J].Oncotarget,2016,7(16):21939-21951.
    [18]YARZA R,VELA S,SOLAS M,et al.c-Jun N-terminal Kinase(JNK)Signaling as a therapeutic target for Alzheimer's disease[J].Front pharmacol,2016,6:321.
    [19]JIANGX,KANDA T,WU S,et al.Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity[J].World J Gastroenterol,2014,20(23):7197-7206.
    [20]KIM S,ISHIDA H,YAMANE D,et al.Contrastin roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus:MKNK1facilitates cell entry[J].J Virol,2013,87(8):4214-4224.
    [21]ZHANG YH,WANG SQ,SUN CR,et al.Inhibition of JNK1 expression decreases migration and invasion of mouse hepatocellular carcinoma cell line in vitro[J].Med Oncol,2011,28(4):966-972.
    [22]NI Z,WANG B,DAI X,et al.HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS-JNK-autophagy pathway[J].Free Radic Biol Med,2014,70:194-203.
    [23]KOMODA F,SHINO Y,HIRNO T,et al.MEKK1 induces c-Jun complexes that act as negative regulators for cell survival and proliferation of HCC cells[J].Int J Oncol,2002,21(3):553-559.
    [24]ZHONG C,LI HD,LIU DY,et al.Clinical study of hepatectomy combined with jianpi huayu therapy for hepatocellular carcinoma[J].Asian Pac J Cancer Prev,2014,15(14):5951-5957.
    [25]ZHANG Z,ZHOU X,SHEN H,et al.Phosphorylated ERK is a potential predictor of sensitivity to sorafenib when treating hepatocellular carcinoma:evidence from an in vitro study[J].BMC Med,2009,24(7):41-53.
    [26]GOPALAN B,NARAYANAN K,KE Z,et al.Therapeutic effect of a multi-targeted imidazolium compound in hepatocellular carcinoma[J].Biomaterials,2014,35(26):7479-7487.
    [27]ZHANG Z,MIAO L,LV C,et al.Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling pathway in human hepatoma SMMC-7721 cells[J].Cell Death Dis,2013,4(6):e657-e679.
    [28]ZHANG J,LAN SJ,LIU QR,et al.Neuroglobin,a novel intracellular hexa-coordinated globin,functions as a tumor suppressor in hepatocellular carcinoma via Raf/MAPK/Erk[J].Mol Pharmacol,2013,83(5):1109-1119.
    [29]PUSHPAVALLIS S,RAMAIAH MJ,SRINIVAS CH,et al.Effect of Benzothiazole based conjugates in causing apoptosis by Regulating p53,PTEN and MAP Kinase proteins affecting miR-195a and miR-101-1[J].Cancer Cell Int,2011,11(1):36-39.
    [30]LIU J,WEI X,WU Y,et al.Giganteaside D induces ROS-mediated apoptosis in human hepatocellular carcinoma cells through the MAPK pathway[J].Cellular oncology(Dordrecht),2016.[Epub ahead of print]
    [31]ZHU H,CHEN XP,LUO SF,et al.The role of extracellular signalregulated kinase pathway in multidrug resistance of hepatocellular carcinoma[J].Chin J Surg,2007,45(13):917-920.(in Chinese)朱虹,陈孝平,罗顺峰,等.ERK/MAPK通路参与肝癌产生多药耐药的胞内信号传导[J].中华外科杂志,2007,45(13):917-920.
    [32]XI Q,GAO N,YANG Y,et al.Anticancer drugs induce hypomethylation of the acetylcholinesterase promoter via a phosphorylated-p38-DNMT1-ACh E pathway in apoptotic hepatocellular carcinoma cells[J].Int J Biochem Cell Biol,2015,68(11):21-32.
    [33]HUANG G,TANG B,TANG K,et al.Isoquercitrin inhibits the progression of liver cancer in vivo and in vitro via the MAPK signalling pathway[J].Oncol Rep,2014,31(5):2377-2384.
    [34]LIU J,WEN X,LIU B,et al.Diosmetin inhibits the metastasis of hepatocellular carcinoma cells by downregulating the expression levels of MMP2 and MMP9[J].Mol Med Reps,2016,13(3):2401-2408.
    [35]LIAO YJ,BAI HY,LI ZH,et al.Longikaurin A,a natural ent-kaurane,induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells[J].Cell Death Dis,2014,5(3):e1137.
    [36]TAN J,LAI Z,LIU L,et al.ONTD induces apoptosis of human hepatoma Bel-7402 cells via a MAPK-dependent mitochondrial pathway and the depletion of intracellular glutathione[J].Int J Biochem Cell Biol,2013,45(11):2632-2642.
    [37]YAN F,WANG XM,LIU ZC,et al.JNK1,JNK2,and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells[J].Hepatobiliary Pancreat Dis Int,2010,9(3):287-295.
    [38]HAGIWARA S,KUDO M,NAGAI T,et al.Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma[J].Br J Cancer,2012,106(12):1997-2003.
    [39]CHEN L,SHI Y,JIANG CY,et al.Expression and prognostic role of pan-Ras,Raf-1,p MEK1 and p ERK1/2 in patients with hepatocellular carcinoma[J].Eur J Surg Oncol,2011,37(6):513-520.
    [40]WANG SN,LEE KT,TSAI CJ,et al.Phosphorylated p38 and JNK MAPK proteins in hepatocellular carcinoma[J].Eur J Clin Invest,2012,42(12):1295-1301.
    [41]HAGIWARA S,KUDO M,CHUNG H,et al.Activation of c-Jun N-terminal kinase in non-cancerous liver tissue predicts a high risk of recurrence after hepatic resection for hepatocellular carcinoma[J].Hepatol Res,2012,42(4):394-400.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2108) PDF downloads(489) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return