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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2017
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Article Contents

Effect of pancreatic stellate cell activation regulated by microRNA on fibrosis of chronic pancreatitis

DOI: 10.3969/j.issn.1001-5256.2017.08.042
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  • Received Date: 2017-02-27
  • Published Date: 2017-08-20
  • Chronic pancreatitis is a progressive chronic inflammatory disease and finally progresses to irreversible pancreatic fibrosis. The diagnosis and treatment of chronic pancreatitis is difficult and there are still no effective measures for delaying or reversing fibrosis. This article introduces the research advances in the role of microRNA ( miRNA) in the fibrosis of chronic pancreatitis and points out that pancreatic stellate cell activation is the key step in pancreatic fibrosis. Recent studies have demonstrated that miRNA regulates pancreatic stellate cell activation and participates in the fibrosis of chronic pancreatitis through altering gene expression and mediating signaling pathways and epithelial-mesenchymal transition, and miRNA may become a new target for the treatment of chronic pancreatitis.

     

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