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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 6
Jun.  2020
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Article Contents

Role of bile acid metabolism and related receptors in the development and progression of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2020.06.040
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  • Received Date: 2020-01-08
  • Published Date: 2020-06-20
  • Enterohepatic circulation plays an important role in the pathogenesis of nonalcoholic fatty liver disease( NAFLD). Bile acid is the basic substance of enterohepatic circulation and plays an important role in lipid metabolism,intestinal flora regulation,and host immunity. This article summarizes the research advances in bile acid which acts as a signal molecule to activate bile acid receptors in the liver and intestine,such as farnesoid X receptor,G protein-coupled receptor 5,pregnane X receptor,and vitamin D receptor,and is thus involved in the pathogenesis of NAFLD. It is expected to develop effective drugs for the treatment of NALFD based on the above targets,but there is still a need for further exploration.

     

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