中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 6
Jun.  2020
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Article Contents

Predictive factors for the clinical effect of PD-1/PD-L1 checkpoint inhibitors in treatment of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2020.06.044
  • Published Date: 2020-06-20
  • At present,there is still a lack of uniform treatment strategies for hepatocellular carcinoma( HCC). Immunotherapy,especially PD-1/PD-L1 checkpoint inhibitors,is a novel therapy for HCC and can bring survival benefits to patients with advanced HCC. However,research data show that only a small number of HCC patients can benefit from this treatment regimen. To date,few biomarkers have been reported to predict the clinical effect of PD-1/PD-L1 checkpoint inhibitors in HCC patients. This article reviews the biomarkers studied for HCC and other tumors and explores the possible predictive factors for the clinical effect of PD-1/PD-L1 checkpoint inhibitors in HCC,in order to optimize the selection of treatment population and improve the clinical effect of PD-1/PD-L1 checkpoint inhibitors in the treatment of HCC.

     

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