WT5”BZ]To investigate the effect of HBcAg and HBeAg on TH1/TH2 like cells profile of PBMC of the chronic HBV infection Sixty four cases of chronic HBV infection, according to immunity condition, were divided into ALT normal and ATL abnormal group;also divided into HBeAg positive and anti HBe positive group 20 healthy persons are normal control group, TH1 like cytokines (IL-1, IFN-γ) and TH2 like cytokines (IL-4, IL-10) , produced by PBMC stimulated with HBV specific antigen HBcAg and HBeAg, were measured by ELISA Results show that levels of IL-2 and INF γ produced by HBcAg induced PBMC of ALT normal and abnormal group were greatly higher than that of produced by HBeAg induced PBMC;in contrast, Levels of IL-4 and IL-10 produced by HBcAg induced PBMC were much lower than that produced by HBeAg induced PBMC, To HBeAg and anti HBe positive group, TH1 response was predominating when PBMC were stimulated by HBcAg However TH2 response was predominant when PBMC were stimulated by HBeAg, Normal control group also have similar results It is suggested that HBcAg tends to induce TH1 response and HBeAg tends to induce TH2 response in different immunity condition of the chronic HBV infection [WT5”HZ]
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