慢性乙型肝炎的疫苗治疗免疫学机制的探讨

Vaccinated 13 patients were analyzed for T cell proliferative responses specific for surface antigen and cytokine production by antigen-specific T cells.Serum H BV DNA levels decreased significantly at 6 months after completion of therapy an d thereafter as compared to the baseline ones.Vacccination induced antigen-speci fic CD4+T cell proliferative responses in 6 patients (38.5%) .The production of high levels of interferon-γ and tumor necrosis factor-α by antigen-specific T cells was found in 6 patients who showed significantly lower HBV DNA levels in serum at 6 and 18 months after completion of therapy than those without high lev els of cytokine production.Envelope-specific CD4+T cells indirectly control HB V replication by producing antiviral cytokines in the therapeutic vaccination ag ainst chronic HBV infection.