细胞因子与乙肝肝硬化骨质疏松的关系

To study the relationship between cytokines and osteoporosis in patients with hepatitis B cirrhosis.Bone mineral desity (BMD) and serum levels of BGP、IL-1β、IL-6、TNF-α、urine crosslaps were detected in 61 cirrhosis patients and 30 agematched healthy controls.BMD and the serum levels of BGP in patients with hepatitis B cirrhosis were lower than those in control group.And the serum levels of BGP were much lower in OP group than those in NOP group.The leels of serum BGP had positive relation with the changes of BMD.A significant negative relation was found between urine crosslaps and BMD in OP group but there were no significant relation between them in NOP group.The serum levels of IL-1β、IL-6、TNF-α and urine crosslaps were higher in cirrhosis group than those in the controls, and were much higher in OP group than in NOP group.BMD had negative relations with serum levels of cytokines and urine crosslaps.Osteoporosis exists in cirrhosis patients.Elevation of serum IL-1β、IL-6、TNF-α can accelerate bone resorption and cause osteoporosis.Decrease of IL-1β、IL-6、TNF-α may be very important for prevention and treatment of osteoporosis.