α-SMA和FAK与慢性乙型肝炎肝纤维化的相关性

To explore the correlation of α-SMA, FAK and the hepatic fibrosis after hepatitis B.Liver biopsies were obtained from 42 cases with hepatitis B.The liver tissues were treated with HE, Masson and V-G, and were classified for stages of liver fibrosis.The expression of α-SMA and FAK in fibrotic liver tissue was observed by immune histochemical techniques, and analyzed in half-ration.The level of α-SMA and FAK were different in various stages of hepatic fibrosis (P<0.01) .After analyzing S0 (0.492±0±535 and 0.143±0.378) , S1 (1.571±1.397 and 1.286±1.113) , S2 (2.875±1.885 and 1.875±1.885) , S3 (4.286±0.756 and 4.286±0.756) , and S4 (4.796±0.927 and 4.923±0.954) , it showed that the scores were increased significantly (P<0.05) .α-SMA and FAK were positive related to the stages of hepatic fibrosis (P<0.05) .The expression of α-SMA and FAK might take important action on the process of the hepatic fibrosis.